Building the future of precision nephrology, today.

NephVar

The NephVar database aims to be a molecular dictionary for nephrologists in defining the genetic architecture of early-onset chronic kidney disease and other disorders of the kidney.

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Read the Preprint
Resolving the classification rates and molecular architecture of early-onset chronic kidney disease with NephVar.
NephVar AI Assistant
Ask questions about inherited kidney disease variants, genes, and classifications — powered by the NephVar database.

Disease Groups

01 —
Live
CGN
Chronic Glomerulonephritis
10 genes
C3CD46CFHCFHR5CFICOL4A3COL4A4COL4A5COL4A6FN1
Open database →
02 —
Live
SRNS
Steroid-Resistant Nephrotic Syndrome
38 genes
ACTN4ADCK4ANLNARHGAP24ARHGDIACD2APCOQ2COQ6CRB2CUBN+28 more
Open database →
03 —
Live
CAKUT
Congenital Anomalies of the Kidney & Urinary Tract
36 genes
ACEAGTAGTR1BMP4CHD1LCHRM3DSTYKEYA1FGF20FRAS1+26 more
Open database →
04 —
Live
NPHP
Nephronophthisis-Related Ciliopathies
16 genes
ANKS6CEP164CEP290GLIS2INVSIQCB1NEK8NPHP1NPHP3NPHP4+6 more
Open database →
05 —
Live
USD
Urinary Stone Disease
30 genes
ADCY10AGXTAPRTATP6V0A4ATP6V1B1CA2CASRCLCN5CLCNKBCLDN16+20 more
Open database →

Analysis

01 —
Live
Biophysical
Per-residue structural analysis — AlphaFold2 structures, RSA, secondary structure, pLDDT, and UniProt domains
129 genes · 5 disease panels
CGNCAKUTSRNSUSDNPHP
Open analysis →
02 —
Live
Grammars
Intrinsically disordered region sequence patterning — NARDINI+ z-scores and GIN molecular grammar clusters
74 of 129 genes · 5 disease panels
CGNCAKUTSRNSUSDNPHP
Open analysis →
© NephVar. Licensed under the CC BY-NC-SA 4.0 License.

Disclaimer: The NephVar Database and other information provided on or linked to this site is for theoretical prediction only; caution should be exercised in use. It is provided “as-is” without any warranty of any kind, whether express or implied. For clarity, no warranty is given that use of the information shall not infringe the rights of any third party. The information provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment, and does not constitute medical or other professional advice. Data contained within the NephVar Database is provided for non-commercial research use only under CC BY-NC-SA 4.0 license.