NephVar / Biophysical

Biophysical Analysis

Per-residue structural annotation for inherited kidney disease genes. AlphaFold2 predicted structures, DSSP secondary structure assignment, relative solvent accessibility (RSA), pLDDT confidence, and UniProt domain features. Select a gene to explore its full residue-level biophysical profile.
CGN 10 genes
Chronic Glomerulonephritis
Complement & collagen genes
C3 CD46 CFH CFHR5 CFI COL4A3 COL4A4 COL4A5 COL4A6 FN1
CAKUT 36 genes
Congenital Anomalies of Kidneys & Urinary Tract
Structural developmental genes
BMP4 CHD1L DSTYK EYA1 GATA3 HNF1B MUC1 PAX2 RET ROBO2 SALL1 SIX1 SIX2 SIX5 SOX17 SRGAP1 TBX18 TNXB UMOD UPK3A WNT4 ACE AGT AGTR1 CHRM3 FGF20 FRAS1 FREM1 FREM2 GRIP1 HPSE2 ITGA8 LRIG2 REN TRAP1 KAL1
SRNS 37 genes
Steroid-Resistant Nephrotic Syndrome
Podocyte & slit diaphragm genes
ADCK4 ARHGDIA CD2AP COQ2 COQ6 CRB2 CUBN DGKE EMP2 FAT1 ITGA3 ITGB4 KANK1 KANK2 KANK4 LAMB2 MYO1E NPHS1 NPHS2 NUP93 NUP107 NUP205 PDSS2 PLCE1 PTPRO SCARB2 SMARCAL1 WDR73 XPO5 ACTN4 ANLN ARHGAP24 INF2 LMX1B MYH9 TRPC6 WT1
USD 30 genes
Urinary Stone Disease
Tubular transporter & metabolic genes
ADCY10 AGXT APRT ATP6V0A4 ATP6V1B1 CA2 CASR CLCN5 CLCNKB CLDN16 CLDN19 CYP24A1 FAM20A GRHPR HNF4A HOGA1 HPRT1 KCNJ1 OCRL SLC12A1 SLC22A12 SLC2A9 SLC34A1 SLC34A3 SLC3A1 SLC4A1 SLC7A9 SLC9A3R1 VDR XDH
NPHP 16 genes
Nephronophthisis-Related Ciliopathies
Ciliary & centrosomal genes
NPHP1 INVS NPHP3 NPHP4 IQCB1 CEP290 GLIS2 RPGRIP1L NEK8 SDCCAG8 TMEM67 TTC21B WDR19 ZNF423 CEP164 ANKS6