NephVar / Molecular Grammars / ANKS6

ANKS6 ANKS6

NPHP panel · 871 aa · UniProt Q68DC2 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 20
Residues 22–67 · 45 aa (5.2% of protein) · Min inter-cluster distance: 5.915
A blocks
Sequence
ETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGA
Top exceptional features (|z-score| rank)
A Patch: +8.62Frac A: +5.10Frac Aliphatic: +3.89E/D Ratio: +2.36pro-pro: -2.02Hydrophobicity: +1.97Disorder Promoting: +1.96Frac S: -1.87
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.000
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.864
neg-aro+0.000
neg-ala-0.239
neg-pro-1.746
neg-gly-0.685
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala-0.423
ala-pro-0.571
ala-gly-1.799
pro-pro-2.021
pro-gly-1.519
gly-gly-1.866
Frac A+5.103
Frac C-0.582
Frac D-1.234
Frac E+1.318
Frac F-0.807
Frac G+1.527
Frac H-0.849
Frac I-0.900
Frac K-1.083
Frac L-0.408
Frac M-0.832
Frac N-0.989
Frac P-0.028
Frac Q-1.207
Frac R+0.018
Frac S-1.874
Frac T-0.785
Frac V+0.313
Frac W-0.508
Frac Y-0.609
Frac K+R-0.795
Frac D+E+0.419
Frac Polar-1.797
Frac Aliphatic+3.890
Frac Aromatic-1.123
R/K Ratio+1.328
E/D Ratio+2.361
Frac Chain Expanding-0.259
FCR-0.205
NCPR-0.840
Hydrophobicity+1.967
Disorder Promoting+1.962
Iso point-1.112
PPII-0.074
A Patch+8.623
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 24
Residues 476–539 · 63 aa (7.2% of protein) · Min inter-cluster distance: 3.279
Weak negative charge
Sequence
RGLSSNQPLPFSDEPEPALDSTMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTM
Top exceptional features (|z-score| rank)
Frac T: +1.21pol-neg: +1.06Frac D: +1.06Frac L: +1.05E/D Ratio: -1.01Iso point: -0.94Frac I: -0.90Frac H: -0.85
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.189
pol-hyd-0.714
pol-pos-0.538
pol-neg+1.058
pol-aro+0.000
pol-ala+0.000
pol-pro+0.500
pol-gly+0.000
hyd-hyd-0.497
hyd-pos+0.116
hyd-neg+0.586
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.389
hyd-gly+0.000
pos-pos-0.391
pos-neg-0.147
pos-aro+0.000
pos-ala+0.000
pos-pro+0.655
pos-gly+0.000
neg-neg+0.080
neg-aro+0.000
neg-ala+0.000
neg-pro-0.406
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.451
pro-gly+0.000
gly-gly+0.000
Frac A+0.327
Frac C-0.582
Frac D+1.058
Frac E-0.400
Frac F+0.091
Frac G-0.321
Frac H-0.849
Frac I-0.900
Frac K-0.237
Frac L+1.047
Frac M+0.802
Frac N+0.029
Frac P+0.197
Frac Q-0.504
Frac R-0.045
Frac S-0.209
Frac T+1.209
Frac V-0.731
Frac W-0.508
Frac Y-0.609
Frac K+R-0.207
Frac D+E+0.200
Frac Polar-0.329
Frac Aliphatic+0.524
Frac Aromatic-0.531
R/K Ratio+0.102
E/D Ratio-1.013
Frac Chain Expanding+0.158
FCR+0.015
NCPR-0.287
Hydrophobicity+0.327
Disorder Promoting+0.137
Iso point-0.944
PPII+0.058
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 6
Residues 562–781 · 219 aa (25.1% of protein) · Min inter-cluster distance: 1.068
S patches
Sequence
PPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPVGGGGTDTTPVRPVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQIAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSELPASPAGGSAPVGKKLETSKRPPSGTSTTSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTGI
Top exceptional features (|z-score| rank)
pos-gly: +2.41pol-hyd: +2.06S Patch: +1.84gly-gly: +1.69pro-gly: +1.50Frac S: +1.48pro-pro: +1.29Frac Polar: +1.22
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.120
pol-hyd+2.065
pol-pos+0.593
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+1.158
pol-gly+1.184
hyd-hyd-0.119
hyd-pos+0.559
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.315
hyd-gly+0.355
pos-pos+0.838
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.134
pos-gly+2.409
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.293
pro-gly+1.503
gly-gly+1.693
Frac A-0.247
Frac C-0.582
Frac D-0.575
Frac E-0.805
Frac F-0.032
Frac G+0.646
Frac H+0.487
Frac I+0.021
Frac K-0.110
Frac L-0.111
Frac M-0.597
Frac N-0.110
Frac P+0.015
Frac Q-0.702
Frac R-0.127
Frac S+1.479
Frac T+0.355
Frac V+0.191
Frac W-0.092
Frac Y-0.609
Frac K+R-0.167
Frac D+E-0.891
Frac Polar+1.221
Frac Aliphatic-0.381
Frac Aromatic-0.442
R/K Ratio-0.055
E/D Ratio-0.230
Frac Chain Expanding-0.900
FCR-0.780
NCPR+0.564
Hydrophobicity+0.549
Disorder Promoting+0.606
Iso point+1.074
PPII-0.591
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+0.297
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.841
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130