NephVar / Molecular Grammars

Molecular Grammars

Intrinsically disordered region (IDR) sequence patterning for inherited kidney disease genes, via the NARDINI+ / Grammars of IDRs in the Human Proteome (GIN) resource. Each IDR is assigned to one of 30 molecular grammar clusters based on its 90-feature sequence composition and patterning z-score vector. Genes without a detected IDR are not shown as links.
CGN 6 of 10 genes
Chronic Glomerulonephritis
Complement & collagen genes
CD46 COL4A3 COL4A4 COL4A5 COL4A6 FN1
No IDR detected: C3, CFH, CFHR5, CFI
CAKUT 22 of 36 genes
Congenital Anomalies of Kidneys & Urinary Tract
Structural developmental genes
BMP4 CHD1L EYA1 GATA3 HNF1B MUC1 PAX2 ROBO2 SALL1 SIX1 SIX2 SIX5 SOX17 SRGAP1 TBX18 TNXB UPK3A CHRM3 FREM2 GRIP1 LRIG2 KAL1
No IDR detected: DSTYK, RET, UMOD, WNT4, ACE, AGT, AGTR1, FGF20, FRAS1, FREM1, HPSE2, ITGA8, REN, TRAP1
SRNS 22 of 37 genes
Steroid-Resistant Nephrotic Syndrome
Podocyte & slit diaphragm genes
ADCK4 ARHGDIA CD2AP FAT1 ITGA3 ITGB4 KANK1 KANK2 KANK4 LAMB2 MYO1E NPHS1 NPHS2 NUP107 PLCE1 SMARCAL1 ANLN ARHGAP24 INF2 LMX1B MYH9 WT1
No IDR detected: COQ2, COQ6, CRB2, CUBN, DGKE, EMP2, NUP93, NUP205, PDSS2, PTPRO, SCARB2, WDR73, XPO5, ACTN4, TRPC6
USD 13 of 30 genes
Urinary Stone Disease
Tubular transporter & metabolic genes
ATP6V0A4 CA2 CASR CLDN19 FAM20A HNF4A OCRL SLC12A1 SLC2A9 SLC3A1 SLC4A1 SLC9A3R1 VDR
No IDR detected: ADCY10, AGXT, APRT, ATP6V1B1, CLCN5, CLCNKB, CLDN16, CYP24A1, GRHPR, HOGA1, HPRT1, KCNJ1, SLC22A12, SLC34A1, SLC34A3, SLC7A9, XDH
NPHP 11 of 16 genes
Nephronophthisis-Related Ciliopathies
Ciliary & centrosomal genes
NPHP1 INVS NPHP3 NPHP4 CEP290 GLIS2 RPGRIP1L SDCCAG8 ZNF423 CEP164 ANKS6
No IDR detected: IQCB1, NEK8, TMEM67, TTC21B, WDR19