NephVar / Molecular Grammars / GATA3

GATA3 GATA3

CAKUT panel · 443 aa · UniProt P23771 · 5 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 10
Residues 0–35 · 35 aa (7.9% of protein) · Min inter-cluster distance: 5.981
Well-mixed hydrophobics, enriched in M
Sequence
MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSY
Top exceptional features (|z-score| rank)
Frac H: +6.47Frac W: +2.09pro-pro: -1.86Frac V: +1.82Frac Chain Expanding: -1.54FCR: -1.33Frac K+R: -1.30pol-pro: -1.15
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.824
pol-hyd-0.126
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-1.154
pol-gly+0.000
hyd-hyd+0.055
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.381
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-1.862
pro-gly+0.000
gly-gly+0.000
Frac A-0.372
Frac C-0.582
Frac D+0.141
Frac E-0.924
Frac F-0.807
Frac G-0.423
Frac H+6.469
Frac I-0.900
Frac K-1.083
Frac L-0.044
Frac M+0.638
Frac N-0.073
Frac P+0.017
Frac Q+0.058
Frac R-0.738
Frac S-0.589
Frac T-0.002
Frac V+1.821
Frac W+2.091
Frac Y+1.083
Frac K+R-1.299
Frac D+E-0.641
Frac Polar+1.014
Frac Aliphatic+0.368
Frac Aromatic+1.006
R/K Ratio+0.598
E/D Ratio-1.105
Frac Chain Expanding-1.544
FCR-1.332
NCPR-0.370
Hydrophobicity+0.170
Disorder Promoting-1.061
Iso point-0.170
PPII-0.684
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 6
Residues 103–225 · 122 aa (27.5% of protein) · Min inter-cluster distance: 6.085
S patches
Sequence
GSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPY
Top exceptional features (|z-score| rank)
Frac H: +1.85Frac Y: +1.33FCR: -1.33Frac Aromatic: +1.32Frac S: +1.32Frac Chain Expanding: -1.12hyd-hyd: -1.03Hydrophobicity: +1.01
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.623
pol-hyd-0.243
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.631
pol-gly+0.000
hyd-hyd-1.035
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.535
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.676
pro-gly+0.000
gly-gly+0.000
Frac A-0.368
Frac C-0.023
Frac D-0.445
Frac E-0.984
Frac F+0.584
Frac G-0.022
Frac H+1.850
Frac I-0.074
Frac K-0.355
Frac L+0.432
Frac M+0.012
Frac N-0.726
Frac P+0.605
Frac Q-0.844
Frac R-0.979
Frac S+1.320
Frac T+0.371
Frac V-0.413
Frac W+0.238
Frac Y+1.333
Frac K+R-0.918
Frac D+E-0.967
Frac Polar+0.912
Frac Aliphatic-0.285
Frac Aromatic+1.321
R/K Ratio-0.864
E/D Ratio-0.862
Frac Chain Expanding-1.120
FCR-1.328
NCPR+0.127
Hydrophobicity+1.007
Disorder Promoting-0.270
Iso point+0.132
PPII-0.228
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.007
Q Patch-0.160
R Patch-0.247
S Patch+0.723
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 25
Residues 232–264 · 32 aa (7.2% of protein) · Min inter-cluster distance: 1.516
Blocks of positive residues
Sequence
LFPPSSLLGGSPTGFGCKSRPKARSSTGRECV
Top exceptional features (|z-score| rank)
Frac C: +3.68Frac F: +2.73hyd-pos: +2.16pos-gly: +1.87hyd-hyd: +1.68Hydrophobicity: +1.61Frac D+E: -1.27Frac D: -1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.181
pol-hyd+0.384
pol-pos-0.444
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-0.164
pol-gly-0.940
hyd-hyd+1.681
hyd-pos+2.163
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.167
hyd-gly+0.084
pos-pos+0.961
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.283
pos-gly+1.874
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.089
pro-gly+0.696
gly-gly+0.584
Frac A-0.847
Frac C+3.680
Frac D-1.234
Frac E-0.884
Frac F+2.728
Frac G+1.179
Frac H-0.849
Frac I-0.900
Frac K+0.027
Frac L+1.005
Frac M-0.832
Frac N-0.989
Frac P+0.169
Frac Q-1.207
Frac R+0.555
Frac S+0.936
Frac T+0.118
Frac V-0.169
Frac W-0.508
Frac Y-0.609
Frac K+R+0.390
Frac D+E-1.267
Frac Polar+0.847
Frac Aliphatic-0.812
Frac Aromatic+1.206
R/K Ratio+0.170
E/D Ratio+0.358
Frac Chain Expanding-0.695
FCR-0.698
NCPR+1.215
Hydrophobicity+1.606
Disorder Promoting-0.933
Iso point+1.208
PPII-0.785
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 4 Cluster 23
Residues 355–394 · 39 aa (8.8% of protein) · Min inter-cluster distance: 17.494
K blocks
Sequence
MKKEGIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPA
Top exceptional features (|z-score| rank)
K Patch: +3.31Frac K: +3.02Frac F: +2.09Frac K+R: +2.05pos-neg: +2.00Frac M: +1.81NCPR: +1.69Disorder Promoting: -1.51
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.148
pol-hyd+0.177
pol-pos-0.198
pol-neg+1.264
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-1.208
hyd-pos+0.255
hyd-neg-1.387
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+1.055
pos-neg+2.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+1.229
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.950
Frac C+1.166
Frac D+0.000
Frac E-0.583
Frac F+2.093
Frac G-0.933
Frac H+0.089
Frac I+0.392
Frac K+3.016
Frac L-0.946
Frac M+1.807
Frac N+1.478
Frac P-0.876
Frac Q-0.639
Frac R-0.287
Frac S+0.432
Frac T-0.709
Frac V-0.374
Frac W-0.508
Frac Y-0.609
Frac K+R+2.054
Frac D+E-0.447
Frac Polar-0.233
Frac Aliphatic-0.851
Frac Aromatic+0.788
R/K Ratio-1.403
E/D Ratio-0.565
Frac Chain Expanding+0.553
FCR+1.009
NCPR+1.690
Hydrophobicity-0.884
Disorder Promoting-1.508
Iso point+0.872
PPII-0.215
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch+3.305
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 5 Cluster 6
Residues 395–443 · 48 aa (10.8% of protein) · Min inter-cluster distance: 1.046
S patches
Sequence
LSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTAMG
Top exceptional features (|z-score| rank)
Frac M: +4.53Frac H: +4.49S Patch: +2.58Frac S: +2.19Frac Chain Expanding: -2.17FCR: -2.14Iso point: +1.88Hydrophobicity: +1.87
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.780
pol-hyd-0.489
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-0.099
pol-gly+0.000
hyd-hyd-0.053
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.365
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.789
pro-gly+0.000
gly-gly+0.000
Frac A-1.038
Frac C-0.582
Frac D-1.234
Frac E-1.354
Frac F+1.549
Frac G-0.674
Frac H+4.487
Frac I+0.150
Frac K-1.083
Frac L+0.706
Frac M+4.528
Frac N-0.989
Frac P+0.465
Frac Q-1.207
Frac R-0.891
Frac S+2.185
Frac T+0.586
Frac V-0.550
Frac W-0.508
Frac Y-0.609
Frac K+R-1.401
Frac D+E-1.627
Frac Polar+1.564
Frac Aliphatic+0.718
Frac Aromatic+0.430
R/K Ratio+0.598
E/D Ratio-0.565
Frac Chain Expanding-2.170
FCR-2.142
NCPR+0.309
Hydrophobicity+1.870
Disorder Promoting-1.307
Iso point+1.881
PPII-0.744
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.168
Q Patch-0.160
R Patch-0.247
S Patch+2.579
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130