NephVar / Molecular Grammars / ITGB4

ITGB4 ITB4

SRNS panel · 1822 aa · UniProt P16144 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 20
Residues 1106–1141 · 35 aa (1.9% of protein) · Min inter-cluster distance: 3.028
A blocks
Sequence
ELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSR
Top exceptional features (|z-score| rank)
ala-pro: +2.45hyd-pro: +2.43hyd-ala: +2.08pol-ala: +1.49Frac V: -1.31ala-ala: +1.28pro-pro: +1.20E/D Ratio: -1.10
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.097
pol-hyd+0.036
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+1.486
pol-pro+0.281
pol-gly+0.000
hyd-hyd+0.750
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+2.078
hyd-pro+2.427
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+1.284
ala-pro+2.454
ala-gly+0.000
pro-pro+1.203
pro-gly+0.000
gly-gly+0.000
Frac A+0.677
Frac C-0.582
Frac D+0.141
Frac E-0.924
Frac F+0.809
Frac G+0.039
Frac H+0.196
Frac I-0.900
Frac K-0.576
Frac L+0.774
Frac M+0.638
Frac N+0.844
Frac P+0.422
Frac Q+0.691
Frac R-0.171
Frac S+0.267
Frac T-0.643
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R-0.543
Frac D+E-0.641
Frac Polar+0.451
Frac Aliphatic+0.368
Frac Aromatic-0.058
R/K Ratio+0.294
E/D Ratio-1.105
Frac Chain Expanding-0.677
FCR-0.837
NCPR+0.127
Hydrophobicity+0.214
Disorder Promoting-0.034
Iso point+0.401
PPII+0.091
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 0
Residues 1395–1448 · 53 aa (2.9% of protein) · Min inter-cluster distance: 2.622
Blocks of G & polar residues
Sequence
LIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMD
Top exceptional features (|z-score| rank)
Frac G: +2.01hyd-gly: +1.91hyd-hyd: +1.73pol-gly: +1.45G Patch: +1.41hyd-pro: +1.32E/D Ratio: -1.25neg-neg: +1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.307
pol-hyd+0.104
pol-pos+0.000
pol-neg+1.046
pol-aro+0.000
pol-ala+0.000
pol-pro+0.889
pol-gly+1.447
hyd-hyd+1.726
hyd-pos+0.000
hyd-neg+0.930
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+1.321
hyd-gly+1.906
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+1.229
neg-aro+0.000
neg-ala+0.000
neg-pro+0.356
neg-gly+1.169
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.013
pro-gly+0.903
gly-gly-0.052
Frac A+0.311
Frac C-0.582
Frac D+0.582
Frac E-0.787
Frac F-0.807
Frac G+2.009
Frac H+0.531
Frac I+0.051
Frac K-0.748
Frac L+0.481
Frac M+0.139
Frac N-0.384
Frac P+0.537
Frac Q-1.207
Frac R+0.192
Frac S+0.106
Frac T-0.860
Frac V-0.622
Frac W-0.508
Frac Y-0.609
Frac K+R-0.429
Frac D+E-0.324
Frac Polar+0.319
Frac Aliphatic+0.333
Frac Aromatic-1.123
R/K Ratio+0.833
E/D Ratio-1.245
Frac Chain Expanding-0.230
FCR-0.525
NCPR-0.037
Hydrophobicity+0.670
Disorder Promoting+0.847
Iso point-0.271
PPII-0.495
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+1.412
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.224
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 6
Residues 1492–1525 · 33 aa (1.8% of protein) · Min inter-cluster distance: 16.517
S patches
Sequence
NSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTA
Top exceptional features (|z-score| rank)
Frac T: +2.79Frac H: +2.48Frac S: +2.21PPII: -2.05S Patch: +1.92Frac Polar: +1.90Frac L: +1.79Frac Chain Expanding: -1.71
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.726
pol-hyd-0.269
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-1.037
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.864
Frac C-0.582
Frac D+0.225
Frac E-0.898
Frac F-0.807
Frac G-1.347
Frac H+2.477
Frac I-0.900
Frac K-1.083
Frac L+1.791
Frac M-0.832
Frac N-0.017
Frac P-1.174
Frac Q-1.207
Frac R+0.498
Frac S+2.214
Frac T+2.795
Frac V-0.204
Frac W-0.508
Frac Y+1.186
Frac K+R-0.474
Frac D+E-0.581
Frac Polar+1.899
Frac Aliphatic-0.394
Frac Aromatic+0.006
R/K Ratio+1.328
E/D Ratio-1.105
Frac Chain Expanding-1.710
FCR-0.748
NCPR+0.127
Hydrophobicity+0.381
Disorder Promoting-0.252
Iso point+0.401
PPII-2.049
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.916
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130