COL4A4 CO4A4
IDR map — colored by GIN molecular grammar cluster
IDR 1
Cluster 22
Residues 57–175 · 118 aa
(7.0% of protein) · Min inter-cluster distance: 67.233
Well-mixed P and G
Sequence
V P E K G S R G PP G PP G P Q G P I G P L G A P G P I G L S G E K G M R G D R G PP G AA G D K G D K G P T G V P G F P G L D G I P G H P G PP G P R G K P G M S G HN G S R G D P G F P GG R G A L G P GG P L G H P G E K G E K G NS
Top exceptional features (|z-score| rank)
RG Frac: +14.16 G Patch: +10.25 Frac G: +4.13 gly-gly: -3.22 hyd-gly: -2.31 pro-gly: -2.11 pos-gly: -2.09 pol-gly: -1.70
Show all 90 sequence-feature z-scores
Feature Z-score pol-pol -0.212 pol-hyd -0.234 pol-pos +0.326 pol-neg +0.000 pol-aro +0.000 pol-ala +0.000 pol-pro +1.070 pol-gly -1.699 hyd-hyd -0.572 hyd-pos +0.684 hyd-neg +0.000 hyd-aro +0.000 hyd-ala +0.000 hyd-pro +0.167 hyd-gly -2.308 pos-pos +0.599 pos-neg +0.000 pos-aro +0.000 pos-ala +0.000 pos-pro +1.444 pos-gly -2.087 neg-neg +0.000 neg-aro +0.000 neg-ala +0.000 neg-pro +0.000 neg-gly +0.000 aro-aro +0.000 aro-ala +0.000 aro-pro +0.000 aro-gly +0.000 ala-ala +0.000 ala-pro +0.000 ala-gly +0.000 pro-pro +0.409 pro-gly -2.109 gly-gly -3.218 Frac A -0.798 Frac C -0.582 Frac D -0.214 Frac E -0.844 Frac F +0.152 Frac G +4.134 Frac H +0.081 Frac I +0.382 Frac K -0.029 Frac L -0.467 Frac M +0.040 Frac N -0.446 Frac P +1.521 Frac Q -1.020 Frac R -0.296 Frac S -1.239 Frac T -1.094 Frac V -0.692 Frac W -0.508 Frac Y -0.609 Frac K+R -0.219 Frac D+E -0.749 Frac Polar +0.571 Frac Aliphatic -1.149 Frac Aromatic -0.491 R/K Ratio -0.274 E/D Ratio -0.807 Frac Chain Expanding +0.259 FCR -0.707 NCPR +0.422 Hydrophobicity +0.330 Disorder Promoting +1.123 Iso point +0.805 PPII +0.304 A Patch -0.265 C Patch -0.009 D Patch -0.178 E Patch -0.349 F Patch -0.012 G Patch +10.249 H Patch -0.077 I Patch -0.011 K Patch -0.253 L Patch -0.096 M Patch -0.026 N Patch -0.076 P Patch +1.618 Q Patch -0.160 R Patch -0.247 S Patch -0.481 T Patch -0.147 V Patch -0.051 Y Patch -0.022 RG Frac +14.163
IDR 2
Cluster 22
Residues 186–263 · 77 aa
(4.6% of protein) · Min inter-cluster distance: 12.694
Well-mixed P and G
Sequence
G D R G D P G L P G L P G S W G A GG P A G P T G Y P G E P G LV G PP G Q P G R P G L K G N P G V G V K G Q M G D P G E V G QQ G S P G P T LLV E PP
Top exceptional features (|z-score| rank)
G Patch: +9.66 Frac G: +3.90 pro-gly: -1.72 gly-gly: -1.68 Frac P: +1.53 pol-gly: -1.51 Frac S: -1.48 FCR: -1.20
Show all 90 sequence-feature z-scores
Feature Z-score pol-pol -0.606 pol-hyd +0.584 pol-pos +0.000 pol-neg +0.000 pol-aro +0.000 pol-ala +0.000 pol-pro -0.886 pol-gly -1.509 hyd-hyd +0.579 hyd-pos +0.000 hyd-neg +0.000 hyd-aro +0.000 hyd-ala +0.000 hyd-pro -0.563 hyd-gly -0.576 pos-pos +0.000 pos-neg +0.000 pos-aro +0.000 pos-ala +0.000 pos-pro +0.000 pos-gly +0.000 neg-neg +0.000 neg-aro +0.000 neg-ala +0.000 neg-pro +0.000 neg-gly +0.000 aro-aro +0.000 aro-ala +0.000 aro-pro +0.000 aro-gly +0.000 ala-ala +0.000 ala-pro +0.000 ala-gly +0.000 pro-pro -0.998 pro-gly -1.722 gly-gly -1.681 Frac A -0.944 Frac C -0.582 Frac D -0.296 Frac E -0.768 Frac F -0.807 Frac G +3.903 Frac H -0.849 Frac I -0.900 Frac K -0.622 Frac L +0.551 Frac M -0.163 Frac N -0.573 Frac P +1.527 Frac Q -0.057 Frac R -0.789 Frac S -1.484 Frac T -0.701 Frac V +1.062 Frac W +0.674 Frac Y +0.160 Frac K+R -0.990 Frac D+E -0.730 Frac Polar +0.579 Frac Aliphatic -0.394 Frac Aromatic -0.155 R/K Ratio -0.133 E/D Ratio -0.565 Frac Chain Expanding -0.309 FCR -1.197 NCPR -0.099 Hydrophobicity +1.009 Disorder Promoting +0.059 Iso point -0.944 PPII +0.442 A Patch -0.265 C Patch -0.009 D Patch -0.178 E Patch -0.349 F Patch -0.012 G Patch +9.662 H Patch -0.077 I Patch -0.011 K Patch -0.253 L Patch -0.096 M Patch -0.026 N Patch -0.076 P Patch +0.704 Q Patch -0.160 R Patch -0.247 S Patch -0.481 T Patch -0.147 V Patch -0.051 Y Patch -0.022 RG Frac -0.130
IDR 3
Cluster 22
Residues 276–328 · 52 aa
(3.1% of protein) · Min inter-cluster distance: 27.059
Well-mixed P and G
Sequence
I P G MV G L P G PP G RK G E S G I G A K G E K G I P G F P G P R G D P G S Y G S P G F P G L K G E L
Top exceptional features (|z-score| rank)
G Patch: +9.96 Frac G: +3.94 gly-gly: -2.13 Frac I: +2.01 pos-gly: -1.47 Frac F: +1.37 Frac T: -1.28 pro-gly: -1.27
Show all 90 sequence-feature z-scores
Feature Z-score pol-pol +0.000 pol-hyd +0.000 pol-pos +0.000 pol-neg +0.000 pol-aro +0.000 pol-ala +0.000 pol-pro +0.000 pol-gly +0.000 hyd-hyd +1.017 hyd-pos +0.949 hyd-neg +0.000 hyd-aro +0.000 hyd-ala +0.000 hyd-pro +0.336 hyd-gly -1.005 pos-pos +0.376 pos-neg +0.000 pos-aro +0.000 pos-ala +0.000 pos-pro +0.423 pos-gly -1.474 neg-neg +0.000 neg-aro +0.000 neg-ala +0.000 neg-pro +0.000 neg-gly +0.000 aro-aro +0.000 aro-ala +0.000 aro-pro +0.000 aro-gly +0.000 ala-ala +0.000 ala-pro +0.000 ala-gly +0.000 pro-pro +0.192 pro-gly -1.266 gly-gly -2.131 Frac A -1.068 Frac C -0.582 Frac D -0.771 Frac E -0.487 Frac F +1.368 Frac G +3.939 Frac H -0.849 Frac I +2.009 Frac K +0.283 Frac L -0.028 Frac M +0.158 Frac N -0.989 Frac P +1.124 Frac Q -1.207 Frac R -0.542 Frac S -1.009 Frac T -1.284 Frac V -0.608 Frac W -0.508 Frac Y +0.530 Frac K+R -0.150 Frac D+E -0.742 Frac Polar +0.019 Frac Aliphatic -0.537 Frac Aromatic +1.027 R/K Ratio -0.672 E/D Ratio +0.358 Frac Chain Expanding +0.035 FCR -0.657 NCPR +0.462 Hydrophobicity +1.261 Disorder Promoting -0.242 Iso point +0.738 PPII +0.023 A Patch -0.265 C Patch -0.009 D Patch -0.178 E Patch -0.349 F Patch -0.012 G Patch +9.961 H Patch -0.077 I Patch -0.011 K Patch -0.253 L Patch -0.096 M Patch -0.026 N Patch -0.076 P Patch -0.447 Q Patch -0.160 R Patch -0.247 S Patch -0.481 T Patch -0.147 V Patch -0.051 Y Patch -0.022 RG Frac -0.130
IDR 4
Cluster 22
Residues 335–1458 · 1123 aa
(66.4% of protein) · Min inter-cluster distance: 69.44
Well-mixed P and G
Note: this region spans the majority of the protein sequence, which may indicate a structured domain (e.g. a collagen triple helix or repetitive fibrous domain) that AlphaFold2 monomer predictions and sequence-based disorder predictors can misclassify as disordered. Interpret this grammar assignment with caution.
Sequence
L F G LI G P K G D P G N R G H P G PP G VLV T PP L P L K G PP G D P G F P G R Y G E T G D V G PP G PP G LL G R P G E A C A G MI G PP G P Q G F P G L P G L P G E A G I P G R P D S A P G K P G K P G S P G L P G A P G L Q G L P G SS VI Y CS V G N P G P Q G I K G K V G PP GG R G P K G E K G N E G L C A C E P G P M G PP G PP G L P G R Q G S K G D L G L P G W L G T K G D P G PP G A E G PP G L P G K H G A S G PP G N K G A K G D MVV S R V K G H K G E R G P D G PP G F P G Q P G SH G R D G H A G E K G D P G PP G D H ED A T P GG K G F P G P L G PP G K A G P V G PP G L G F P G PP G E R G H P G V P G H P G V R G P D G L K G Q K G D T I SCN V T Y P G R H G PP G F D G PP G P K G F P G P Q G A P G L S G S D G H K G R P G T P G T A E I P G PP G F R G D M G D P G F GG E K G SS P V G PP G PP G S P G V N G Q K G I P G D P A F G H L G PP G KR G L S G V P G I K G P R G D P G C P G A E G P A G I P G F L G L K G P K G R E G H A G F P G V P G PP G HSC E R G A P G I P G Q P G L P G Y P G S P G A P GG K G Q P G D V G PP G P A G M K G L P G L P G R P G A H G PP G L P G I P G P F G DD G L P G PP G P K G P R G L P G F P G F P G E R G K P G A E G C P G A K G E P G E K G M S G L P G D R G L R G A K G A I G PP G DE G E M A II SQ K G T P G E P G PP G DD G F P G E R G D K G T P G M Q G RR G E P G R Y G PP G F H R G E P G E K G Q P G PP G PP G PP G ST G L R G F I G F P G L P G D Q G E P G S P G PP G F S G I D G A R G P K G N K G D P A SH F G PP G P K G E P G S P G C P G H F G A S G E Q G L P G I Q G P R G S P G R P G PP G SS G PP G C P G D H G M P G L R G Q P G E M G D P G P R G L Q G D P G I P G PP G I K G P S G S P G L N G L H G L K G Q K G T K G A S G L H D V G PP G P V G I P G L K G E R G D P G S P G I S PP G P R G KK G PP G PP G SS G PP G P A G A T G R A P K D I P D P G PP G D Q G PP G P D G P R G A P G PP G L P G S V D LL R G E P G D C G L P G PP G PP G PP G PP G Y K G F P G C D G K D G Q K G P V G F P G P Q G P H G F P G PP G E K G L P G PP G RK G P T G L P G P R G E P G PP A D V DD C P R I P G L P G A P G M R G P E G A M G L P G M R G P S G P G C K G E P G L D G RR G V D G V P G S P G PP G RK G D T G ED G Y P GG P G PP G P I G D P G P K G F
Top exceptional features (|z-score| rank)
G Patch: +9.51 gly-gly: -8.39 RG Frac: +8.26 pro-gly: -7.27 hyd-gly: -6.09 pol-gly: -6.06 Frac G: +3.69 Frac P: +1.82
Show all 90 sequence-feature z-scores
Feature Z-score pol-pol -0.083 pol-hyd -0.937 pol-pos +0.000 pol-neg +0.000 pol-aro +0.000 pol-ala +0.000 pol-pro +1.678 pol-gly -6.062 hyd-hyd -0.085 hyd-pos +0.000 hyd-neg +0.000 hyd-aro +0.000 hyd-ala +0.000 hyd-pro +0.221 hyd-gly -6.089 pos-pos +0.000 pos-neg +0.000 pos-aro +0.000 pos-ala +0.000 pos-pro +0.000 pos-gly +0.000 neg-neg +0.000 neg-aro +0.000 neg-ala +0.000 neg-pro +0.000 neg-gly +0.000 aro-aro +0.000 aro-ala +0.000 aro-pro +0.000 aro-gly +0.000 ala-ala +0.000 ala-pro +0.000 ala-gly +0.000 pro-pro -0.629 pro-gly -7.274 gly-gly -8.394 Frac A -0.800 Frac C +0.268 Frac D -0.120 Frac E -0.845 Frac F +0.553 Frac G +3.692 Frac H -0.165 Frac I +0.222 Frac K -0.182 Frac L -0.329 Frac M -0.236 Frac N -0.761 Frac P +1.819 Frac Q -0.773 Frac R -0.474 Frac S -1.353 Frac T -0.984 Frac V -0.498 Frac W -0.427 Frac Y -0.240 Frac K+R -0.452 Frac D+E -0.705 Frac Polar +0.344 Frac Aliphatic -1.124 Frac Aromatic +0.039 R/K Ratio -0.333 E/D Ratio -0.973 Frac Chain Expanding +0.332 FCR -0.826 NCPR +0.236 Hydrophobicity +0.584 Disorder Promoting +0.791 Iso point +0.401 PPII +0.679 A Patch -0.265 C Patch -0.009 D Patch -0.178 E Patch -0.349 F Patch -0.012 G Patch +9.511 H Patch -0.077 I Patch -0.011 K Patch -0.253 L Patch -0.096 M Patch -0.026 N Patch -0.076 P Patch +1.703 Q Patch -0.160 R Patch -0.247 S Patch -0.481 T Patch -0.147 V Patch -0.051 Y Patch -0.022 RG Frac +8.264