NephVar / Molecular Grammars / PAX2

PAX2 PAX2

CAKUT panel · 417 aa · UniProt Q02962 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 15
Residues 142–181 · 39 aa (9.4% of protein) · Min inter-cluster distance: 5.139
T patches
Sequence
VQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDP
Top exceptional features (|z-score| rank)
Frac V: +2.44E/D Ratio: -2.03FCR: -1.88Frac L: -1.68Frac K+R: -1.68pol-ala: -1.63Frac T: +1.59Hydrophobicity: +1.57
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.884
pol-hyd-0.550
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala-1.634
pol-pro-0.919
pol-gly-0.109
hyd-hyd+0.216
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala-0.118
hyd-pro-0.504
hyd-gly+0.409
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala-1.473
ala-pro-0.545
ala-gly-1.019
pro-pro-0.430
pro-gly+0.694
gly-gly+1.130
Frac A+0.461
Frac C-0.582
Frac D+0.000
Frac E-1.354
Frac F+0.643
Frac G+0.311
Frac H+1.027
Frac I+0.392
Frac K-1.083
Frac L-1.681
Frac M-0.832
Frac N-0.167
Frac P+1.306
Frac Q-0.072
Frac R-1.304
Frac S+0.048
Frac T+1.593
Frac V+2.436
Frac W-0.508
Frac Y-0.609
Frac K+R-1.677
Frac D+E-1.037
Frac Polar+1.028
Frac Aliphatic+0.404
Frac Aromatic-0.167
R/K Ratio-0.133
E/D Ratio-2.028
Frac Chain Expanding-1.262
FCR-1.878
NCPR-0.319
Hydrophobicity+1.572
Disorder Promoting+0.334
Iso point-0.675
PPII+0.783
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 10
Residues 302–368 · 66 aa (15.8% of protein) · Min inter-cluster distance: 2.111
Well-mixed hydrophobics, enriched in M
Sequence
VKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFS
Top exceptional features (|z-score| rank)
Frac Y: +2.08Frac V: +2.01Frac T: +1.78Hydrophobicity: +1.71Frac Chain Expanding: -1.71FCR: -1.67gly-gly: -1.39Disorder Promoting: -1.34
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.132
pol-hyd-0.367
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.293
pol-gly-0.284
hyd-hyd-1.070
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.511
hyd-gly-1.289
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.131
pro-gly-0.334
gly-gly-1.393
Frac A-0.586
Frac C-0.582
Frac D-0.870
Frac E-0.898
Frac F+0.050
Frac G+0.613
Frac H-0.295
Frac I-0.900
Frac K-0.814
Frac L+0.055
Frac M+0.727
Frac N-0.017
Frac P+0.330
Frac Q-0.536
Frac R-1.004
Frac S+0.624
Frac T+1.776
Frac V+2.011
Frac W-0.508
Frac Y+2.083
Frac K+R-1.276
Frac D+E-1.104
Frac Polar+1.154
Frac Aliphatic+0.347
Frac Aromatic+1.135
R/K Ratio-0.133
E/D Ratio-0.025
Frac Chain Expanding-1.710
FCR-1.666
NCPR-0.005
Hydrophobicity+1.712
Disorder Promoting-1.341
Iso point-0.675
PPII-0.378
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.063
Q Patch-0.160
R Patch-0.247
S Patch+0.546
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130