NephVar / Molecular Grammars / EYA1

EYA1 EYA1

CAKUT panel · 592 aa · UniProt Q99502 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 10
Residues 0–111 · 111 aa (18.8% of protein) · Min inter-cluster distance: 0.729
Well-mixed hydrophobics, enriched in M
Sequence
MEMQDLTSPHSRLSGSSESPSGPKLGNSHINSNSMTPNGTEVKTEPMSSSETASTTADGSLNNFSGSAIGSSSFSPRPTHQFSPPQIYPSNRPYPHILPTPSSQTMAAYGQ
Top exceptional features (|z-score| rank)
hyd-hyd: -1.77Frac S: +1.50Frac Chain Expanding: -1.49Frac M: +1.49Frac Polar: +1.46S Patch: +1.45FCR: -1.39pol-hyd: -1.22
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.054
pol-hyd-1.215
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-0.302
pol-gly+0.000
hyd-hyd-1.773
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.610
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.016
pro-gly+0.000
gly-gly+0.000
Frac A-0.594
Frac C-0.582
Frac D-0.801
Frac E-0.677
Frac F+0.721
Frac G-0.182
Frac H+0.469
Frac I+0.917
Frac K-0.763
Frac L-0.391
Frac M+1.486
Frac N+1.034
Frac P+0.185
Frac Q-0.210
Frac R-0.768
Frac S+1.502
Frac T+0.737
Frac V-0.982
Frac W-0.508
Frac Y+0.992
Frac K+R-1.081
Frac D+E-0.901
Frac Polar+1.464
Frac Aliphatic-0.421
Frac Aromatic+0.891
R/K Ratio+0.170
E/D Ratio+0.358
Frac Chain Expanding-1.487
FCR-1.386
NCPR-0.030
Hydrophobicity+0.629
Disorder Promoting-0.973
Iso point-0.271
PPII-0.428
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.453
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 28
Residues 231–322 · 91 aa (15.4% of protein) · Min inter-cluster distance: 3.002
High aromatic fraction, specifically Ys
Sequence
SSPYPAHYMTSSNTSPTTPSTNATYQLQEPPSGITSQAVTDPTAEYSTIHSPSTPIKDSDSDRLRRGSDGKSRGRGRRNNNPSPPPDSDLE
Top exceptional features (|z-score| rank)
T Patch: +3.51RG Frac: +2.52pol-neg: +2.21Frac Y: +1.99E/D Ratio: -1.49Frac T: +1.43pro-pro: +1.42R Patch: +1.29
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.296
pol-hyd+0.000
pol-pos+0.000
pol-neg+2.210
pol-aro+0.000
pol-ala+0.000
pol-pro-0.218
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.773
neg-aro+0.000
neg-ala+0.000
neg-pro+0.951
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.420
pro-gly+0.000
gly-gly+0.000
Frac A-0.614
Frac C-0.582
Frac D+0.617
Frac E-0.858
Frac F-0.807
Frac G-0.459
Frac H-0.045
Frac I+0.762
Frac K-0.693
Frac L-0.737
Frac M-0.266
Frac N+0.773
Frac P+0.422
Frac Q-0.477
Frac R+0.221
Frac S+0.926
Frac T+1.428
Frac V-0.910
Frac W-0.508
Frac Y+1.994
Frac K+R-0.369
Frac D+E-0.362
Frac Polar+0.884
Frac Aliphatic-1.209
Frac Aromatic+0.515
R/K Ratio+0.901
E/D Ratio-1.488
Frac Chain Expanding-0.299
FCR-0.514
NCPR+0.031
Hydrophobicity-0.499
Disorder Promoting+0.203
Iso point-0.406
PPII+0.010
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.161
Q Patch-0.160
R Patch+1.295
S Patch-0.481
T Patch+3.510
V Patch-0.051
Y Patch-0.022
RG Frac+2.518