NephVar / Molecular Grammars / CHRM3

CHRM3 ACM3

CAKUT panel · 590 aa · UniProt P20309 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 6
Residues 264–306 · 42 aa (7.1% of protein) · Min inter-cluster distance: 8.601
S patches
Sequence
LAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRR
Top exceptional features (|z-score| rank)
pos-pos: +1.60E/D Ratio: +1.58Frac Chain Expanding: -1.45PPII: -1.40S Patch: +1.40Frac Polar: +1.39Frac P: -1.27Frac D: -1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.013
pol-hyd-0.156
pol-pos-0.451
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-0.941
hyd-pos+0.193
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+1.604
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.110
Frac C+1.041
Frac D-1.234
Frac E+0.077
Frac F+0.540
Frac G-0.192
Frac H+0.022
Frac I-0.900
Frac K-0.660
Frac L+0.365
Frac M+0.393
Frac N+0.538
Frac P-1.266
Frac Q+0.902
Frac R+0.584
Frac S+0.981
Frac T+0.319
Frac V-0.441
Frac W-0.508
Frac Y+0.801
Frac K+R-0.102
Frac D+E-0.531
Frac Polar+1.388
Frac Aliphatic-0.253
Frac Aromatic+0.652
R/K Ratio+0.833
E/D Ratio+1.579
Frac Chain Expanding-1.447
FCR-0.466
NCPR+0.334
Hydrophobicity+0.064
Disorder Promoting-0.719
Iso point+0.536
PPII-1.403
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.402
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 4
Residues 317–357 · 40 aa (6.8% of protein) · Min inter-cluster distance: 11.686
Weak negative charge, high N fraction
Sequence
KSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDI
Top exceptional features (|z-score| rank)
Frac W: +4.04Frac D: +2.38Frac S: +2.25Frac N: +2.22NCPR: -1.61PPII: -1.36Frac G: -1.35Frac V: -1.31
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.367
pol-hyd+0.000
pol-pos+0.000
pol-neg-0.415
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.715
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+0.414
Frac C-0.582
Frac D+2.377
Frac E+0.149
Frac F-0.807
Frac G-1.347
Frac H+0.065
Frac I+0.360
Frac K-0.195
Frac L-0.965
Frac M+0.455
Frac N+2.219
Frac P-1.249
Frac Q-0.100
Frac R-1.304
Frac S+2.248
Frac T-1.284
Frac V-1.311
Frac W+4.041
Frac Y-0.609
Frac K+R-1.015
Frac D+E+1.250
Frac Polar+0.662
Frac Aliphatic-0.506
Frac Aromatic+0.740
R/K Ratio-1.292
E/D Ratio-1.013
Frac Chain Expanding-0.568
FCR+0.276
NCPR-1.614
Hydrophobicity-0.999
Disorder Promoting-0.483
Iso point-1.179
PPII-1.360
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+0.931
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130