NephVar / Molecular Grammars / NPHS1

NPHS1 NPHN

SRNS panel · 1241 aa · UniProt O60500 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 27
Residues 1021–1057 · 36 aa (2.9% of protein) · Min inter-cluster distance: 6.286
P patches
Sequence
SGLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGP
Top exceptional features (|z-score| rank)
P Patch: +2.01Frac P: +1.55Frac L: +1.50pol-pro: -1.46pol-hyd: -1.44gly-gly: -1.33Frac V: -1.31Frac K+R: -1.31
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.643
pol-hyd-1.438
pol-pos+0.000
pol-neg+0.169
pol-aro+0.000
pol-ala+0.000
pol-pro-1.460
pol-gly-0.926
hyd-hyd-0.856
hyd-pos+0.000
hyd-neg+0.878
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.435
hyd-gly-0.516
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.088
neg-aro+0.000
neg-ala+0.000
neg-pro-0.819
neg-gly-0.257
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.913
pro-gly-0.582
gly-gly-1.333
Frac A-0.911
Frac C-0.582
Frac D+0.103
Frac E-0.101
Frac F-0.807
Frac G+0.898
Frac H+0.167
Frac I+0.500
Frac K-0.590
Frac L+1.502
Frac M-0.832
Frac N-0.989
Frac P+1.548
Frac Q+0.638
Frac R-1.304
Frac S-0.625
Frac T+1.209
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R-1.309
Frac D+E-0.028
Frac Polar+0.608
Frac Aliphatic-0.642
Frac Aromatic-1.123
R/K Ratio-0.864
E/D Ratio-0.182
Frac Chain Expanding+0.078
FCR-0.879
NCPR-0.840
Hydrophobicity+0.341
Disorder Promoting+1.064
Iso point-1.112
PPII+1.160
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+2.014
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 28
Residues 1094–1165 · 71 aa (5.7% of protein) · Min inter-cluster distance: 3.199
High aromatic fraction, specifically Ys
Sequence
EGISEKTEAGSEEDRVRNEYEESQWTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFTGE
Top exceptional features (|z-score| rank)
Frac Y: +2.73Frac Aromatic: +2.55Frac E: +1.61Frac Aliphatic: -1.52Frac T: +1.24E/D Ratio: +1.20R/K Ratio: +1.19Frac D+E: +1.13
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.672
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.454
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.684
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.904
Frac C-0.582
Frac D-0.217
Frac E+1.609
Frac F+0.786
Frac G-0.209
Frac H-0.849
Frac I-0.190
Frac K-0.833
Frac L-0.874
Frac M-0.832
Frac N-0.537
Frac P-0.805
Frac Q+0.040
Frac R+0.371
Frac S+0.237
Frac T+1.244
Frac V+0.233
Frac W+0.774
Frac Y+2.728
Frac K+R-0.373
Frac D+E+1.129
Frac Polar+0.115
Frac Aliphatic-1.523
Frac Aromatic+2.551
R/K Ratio+1.188
E/D Ratio+1.196
Frac Chain Expanding+0.133
FCR+0.605
NCPR-1.099
Hydrophobicity-0.765
Disorder Promoting+0.016
Iso point-1.078
PPII-0.795
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130