NephVar / Molecular Grammars / CHD1L

CHD1L CHD1L

CAKUT panel · 897 aa · UniProt Q86WJ1 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 19
Residues 551–592 · 41 aa (4.6% of protein) · Min inter-cluster distance: 1.448
High negative fraction, specifically Es
Sequence
SDALPAAEGGSRDQEEGKNHMYLFEGKDYSKEPSKEDRKSF
Top exceptional features (|z-score| rank)
Frac Aromatic: +2.51Frac Y: +2.28Frac F: +1.95pos-neg: -1.53pol-pos: -1.38Frac V: -1.31Frac T: -1.28FCR: +1.27
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.376
pol-hyd+0.000
pol-pos-1.381
pol-neg-0.962
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.622
pos-neg-1.528
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-1.107
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.078
Frac C-0.582
Frac D+1.114
Frac E+0.845
Frac F+1.952
Frac G+0.230
Frac H+0.043
Frac I-0.900
Frac K+1.083
Frac L-0.284
Frac M+0.423
Frac N-0.207
Frac P-0.912
Frac Q-0.667
Frac R-0.337
Frac S-0.046
Frac T-1.284
Frac V-1.311
Frac W-0.508
Frac Y+2.280
Frac K+R+0.582
Frac D+E+1.180
Frac Polar-0.885
Frac Aliphatic-0.973
Frac Aromatic+2.512
R/K Ratio-0.864
E/D Ratio-0.117
Frac Chain Expanding+0.832
FCR+1.269
NCPR-0.510
Hydrophobicity-1.066
Disorder Promoting+0.053
Iso point-0.876
PPII-0.905
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 23
Residues 605–673 · 68 aa (7.6% of protein) · Min inter-cluster distance: 9.698
K blocks
Sequence
ASQEGRSLRNKGSVLIPGLVEGSTKRKRVLSPEELEDRQKKRQEAAAKRRRLIEEKKRQKEEAEHKKK
Top exceptional features (|z-score| rank)
Frac K+R: +2.60hyd-pos: +2.47pos-pos: +2.42pos-neg: +2.06Frac K: +2.05FCR: +2.01E/D Ratio: +1.82hyd-hyd: +1.68
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.423
pol-hyd+0.767
pol-pos-0.278
pol-neg+0.326
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+1.677
hyd-pos+2.471
hyd-neg+1.345
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+2.416
pos-neg+2.061
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.901
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.071
Frac C-0.582
Frac D-0.880
Frac E+1.077
Frac F-0.807
Frac G-0.396
Frac H-0.311
Frac I+0.583
Frac K+2.051
Frac L+0.847
Frac M-0.832
Frac N-0.517
Frac P-1.186
Frac Q+0.095
Frac R+1.612
Frac S-0.772
Frac T-0.954
Frac V+0.301
Frac W-0.508
Frac Y-0.609
Frac K+R+2.603
Frac D+E+0.404
Frac Polar-1.450
Frac Aliphatic+0.478
Frac Aromatic-1.123
R/K Ratio-0.310
E/D Ratio+1.822
Frac Chain Expanding+1.499
FCR+2.008
NCPR+1.407
Hydrophobicity-1.178
Disorder Promoting+0.388
Iso point+1.007
PPII-0.059
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130