NephVar / Molecular Grammars / LRIG2

LRIG2 LRIG2

CAKUT panel · 1065 aa · UniProt O94898 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 28
Residues 856–891 · 35 aa (3.3% of protein) · Min inter-cluster distance: 1.22
High aromatic fraction, specifically Ys
Sequence
SSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKG
Top exceptional features (|z-score| rank)
Frac Y: +2.77Frac Polar: +1.86Frac Chain Expanding: -1.83gly-gly: -1.62FCR: -1.33Frac Q: +1.32Frac V: -1.31Frac R: -1.30
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.244
pol-hyd-0.461
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly-1.007
hyd-hyd+0.436
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly-0.023
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly-1.616
Frac A-0.372
Frac C-0.582
Frac D-1.234
Frac E-0.066
Frac F-0.807
Frac G+0.963
Frac H+1.241
Frac I+0.540
Frac K-0.576
Frac L-0.044
Frac M+0.638
Frac N+0.844
Frac P-0.388
Frac Q+1.324
Frac R-1.304
Frac S+0.695
Frac T-0.643
Frac V-1.311
Frac W-0.508
Frac Y+2.775
Frac K+R-1.299
Frac D+E-0.641
Frac Polar+1.857
Frac Aliphatic-0.564
Frac Aromatic+1.006
R/K Ratio-0.864
E/D Ratio+1.282
Frac Chain Expanding-1.833
FCR-1.332
NCPR-0.370
Hydrophobicity-0.062
Disorder Promoting-0.548
Iso point-0.675
PPII-0.826
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 17
Residues 953–996 · 43 aa (4.0% of protein) · Min inter-cluster distance: 0.214
Weak positive charge
Sequence
TTALESLIPSANREPSAFPTNHERISEKKLPSTQMSGETLQRP
Top exceptional features (|z-score| rank)
E/D Ratio: +1.82neg-neg: -1.67Frac I: +1.45pos-neg: -1.35Frac T: +1.32pol-hyd: -1.31Frac V: -1.31hyd-neg: -1.25
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.955
pol-hyd-1.315
pol-pos-0.411
pol-neg-0.857
pol-aro+0.000
pol-ala+0.000
pol-pro-1.167
pol-gly+0.000
hyd-hyd-1.104
hyd-pos-0.247
hyd-neg-1.246
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.331
hyd-gly+0.000
pos-pos+0.666
pos-neg-1.354
pos-aro+0.000
pos-ala+0.000
pos-pro-0.370
pos-gly+0.000
neg-neg-1.670
neg-aro+0.000
neg-ala+0.000
neg-pro-0.178
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-1.072
pro-gly+0.000
gly-gly+0.000
Frac A-0.140
Frac C-0.582
Frac D-1.234
Frac E+0.394
Frac F+0.508
Frac G-0.971
Frac H+0.002
Frac I+1.445
Frac K-0.257
Frac L+0.984
Frac M+0.365
Frac N+0.503
Frac P+0.045
Frac Q-0.177
Frac R+0.079
Frac S+0.217
Frac T+1.325
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R-0.139
Frac D+E-0.289
Frac Polar+0.125
Frac Aliphatic+0.433
Frac Aromatic-0.256
R/K Ratio+0.170
E/D Ratio+1.822
Frac Chain Expanding-0.327
FCR-0.308
NCPR+0.127
Hydrophobicity+0.429
Disorder Promoting-0.619
Iso point+0.401
PPII+0.153
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 6
Residues 998–1044 · 46 aa (4.3% of protein) · Min inter-cluster distance: 1.624
S patches
Sequence
NINRELGLPHPPFSQQPVHESPQLHQNEGLAGREPDCSASSMSCHR
Top exceptional features (|z-score| rank)
Frac C: +2.38Frac H: +2.33pol-pol: +1.62Disorder Promoting: -1.52R/K Ratio: +1.33Frac T: -1.28hyd-hyd: -1.28Frac N: +1.10
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.624
pol-hyd-0.937
pol-pos+0.000
pol-neg+0.365
pol-aro+0.000
pol-ala+0.000
pol-pro-0.060
pol-gly+0.000
hyd-hyd-1.281
hyd-pos+0.000
hyd-neg-0.779
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.090
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.529
neg-aro+0.000
neg-ala+0.000
neg-pro+0.310
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.220
pro-gly+0.000
gly-gly+0.000
Frac A-0.623
Frac C+2.383
Frac D-0.711
Frac E-0.047
Frac F+0.422
Frac G-0.293
Frac H+2.332
Frac I+0.196
Frac K-1.083
Frac L+0.810
Frac M+0.287
Frac N+1.103
Frac P+0.246
Frac Q+0.719
Frac R-0.011
Frac S+0.081
Frac T-1.284
Frac V-0.517
Frac W-0.508
Frac Y-0.609
Frac K+R-0.814
Frac D+E-0.376
Frac Polar+0.940
Frac Aliphatic-0.169
Frac Aromatic-0.313
R/K Ratio+1.328
E/D Ratio+0.656
Frac Chain Expanding-0.777
FCR-0.816
NCPR-0.251
Hydrophobicity+0.162
Disorder Promoting-1.518
Iso point-0.271
PPII-0.187
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+0.993
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130