NephVar / Molecular Grammars / SOX17

SOX17 SOX17

CAKUT panel · 414 aa · UniProt Q9H6I2 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 20
Residues 35–68 · 33 aa (8.0% of protein) · Min inter-cluster distance: 24.233
A blocks
Sequence
LSPIGDMKVKGEAPANSGAPAGAAGRAKGESRI
Top exceptional features (|z-score| rank)
A Patch: +5.19hyd-ala: +2.94Frac Aliphatic: +2.57Frac A: +2.47gly-gly: -2.43hyd-hyd: +2.21Frac I: +2.15Frac G: +1.59
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.064
pol-hyd+0.663
pol-pos+1.204
pol-neg+0.000
pol-aro+0.000
pol-ala+1.022
pol-pro+0.000
pol-gly-0.186
hyd-hyd+2.207
hyd-pos-0.338
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+2.944
hyd-pro+0.000
hyd-gly-0.257
pos-pos+1.046
pos-neg+0.000
pos-aro+0.000
pos-ala+1.568
pos-pro+0.000
pos-gly-0.852
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.924
ala-pro+0.000
ala-gly-1.043
pro-pro+0.000
pro-gly+0.000
gly-gly-2.428
Frac A+2.472
Frac C-0.582
Frac D-0.505
Frac E-0.443
Frac F-0.807
Frac G+1.593
Frac H-0.849
Frac I+2.155
Frac K+0.532
Frac L-0.813
Frac M+0.727
Frac N-0.017
Frac P-0.314
Frac Q-1.207
Frac R-0.103
Frac S-0.511
Frac T-1.284
Frac V-0.204
Frac W-0.508
Frac Y-0.609
Frac K+R+0.327
Frac D+E-0.581
Frac Polar-0.783
Frac Aliphatic+2.572
Frac Aromatic-1.123
R/K Ratio-0.437
E/D Ratio-0.025
Frac Chain Expanding-0.484
FCR-0.223
NCPR+0.655
Hydrophobicity+1.536
Disorder Promoting+0.292
Iso point+0.872
PPII-0.400
A Patch+5.189
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 27
Residues 251–287 · 36 aa (8.7% of protein) · Min inter-cluster distance: 1.92
P patches
Sequence
SYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSIPGLL
Top exceptional features (|z-score| rank)
P Patch: +5.71Frac Y: +2.68Frac P: +2.34gly-gly: -2.26PPII: +1.67pol-pro: +1.54ala-ala: -1.50Hydrophobicity: +1.44
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.318
pol-hyd-1.359
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala-0.872
pol-pro+1.539
pol-gly-0.198
hyd-hyd-0.176
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala-0.102
hyd-pro+0.759
hyd-gly-1.004
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala-1.502
ala-pro-0.218
ala-gly-1.307
pro-pro+0.147
pro-gly-1.005
gly-gly-2.264
Frac A+0.618
Frac C-0.582
Frac D-0.566
Frac E-0.519
Frac F-0.807
Frac G+0.898
Frac H+0.167
Frac I+0.500
Frac K-1.083
Frac L+0.706
Frac M+0.597
Frac N-0.989
Frac P+2.336
Frac Q-0.592
Frac R-0.754
Frac S-0.625
Frac T-1.284
Frac V-0.296
Frac W-0.508
Frac Y+2.681
Frac K+R-1.309
Frac D+E-0.668
Frac Polar-1.032
Frac Aliphatic+1.171
Frac Aromatic+0.947
R/K Ratio+0.598
E/D Ratio-0.025
Frac Chain Expanding+0.078
FCR-1.360
NCPR-0.356
Hydrophobicity+1.443
Disorder Promoting-0.434
Iso point-0.944
PPII+1.666
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+5.705
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 11
Residues 302–357 · 55 aa (13.3% of protein) · Min inter-cluster distance: 6.899
Q-tracts
Sequence
PGAGGGRGFQMQPQHQHQHQHQHHPPGPGQPSPPPEALPCRDGTDPSQPAELLGE
Top exceptional features (|z-score| rank)
H Patch: +9.53Q Patch: +6.27pol-gly: +6.10pol-pol: +4.46Frac H: +3.14pol-pro: +2.88Frac Q: +2.42pro-gly: +1.99
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+4.462
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+2.882
pol-gly+6.104
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.042
pro-gly+1.992
gly-gly+1.703
Frac A-0.420
Frac C+0.658
Frac D-0.359
Frac E-0.534
Frac F+0.221
Frac G+1.299
Frac H+3.142
Frac I-0.900
Frac K-1.083
Frac L-0.118
Frac M+0.104
Frac N-0.989
Frac P+1.491
Frac Q+2.417
Frac R-0.583
Frac S-1.329
Frac T-0.876
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R-1.196
Frac D+E-0.581
Frac Polar+1.243
Frac Aliphatic-1.284
Frac Aromatic-0.445
R/K Ratio+1.025
E/D Ratio-0.182
Frac Chain Expanding-0.362
FCR-1.220
NCPR-0.348
Hydrophobicity-0.733
Disorder Promoting+1.599
Iso point-0.271
PPII+1.100
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+1.150
H Patch+9.533
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.768
Q Patch+6.274
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130