NephVar / Molecular Grammars / NPHS2

NPHS2 PODO

SRNS panel · 383 aa · UniProt Q9NP85 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 29
Residues 0–95 · 95 aa (24.8% of protein) · Min inter-cluster distance: 2.936
High R fraction
Sequence
MERRARSSSRESRGRGGRTPHKENKRAKAERSGGGRGRQEAGPEPSGSGRAGTPGEPRAPAATVVDVDEVRGSGEEGTEVVALLESERPEEGTKS
Top exceptional features (|z-score| rank)
V Patch: +10.71R Patch: +1.97Frac R: +1.83Disorder Promoting: +1.67E/D Ratio: +1.67gly-gly: +1.51pol-pos: -1.39Frac G: +1.38
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.306
pol-hyd+0.000
pol-pos-1.390
pol-neg-0.587
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly-0.216
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.407
pos-neg+0.288
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly-0.050
neg-neg-0.240
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+1.264
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+1.509
Frac A+0.318
Frac C-0.582
Frac D-0.728
Frac E+1.019
Frac F-0.807
Frac G+1.376
Frac H-0.464
Frac I-0.900
Frac K-0.335
Frac L-1.078
Frac M-0.290
Frac N-0.652
Frac P-0.559
Frac Q-0.974
Frac R+1.827
Frac S-0.296
Frac T-0.103
Frac V+0.997
Frac W-0.508
Frac Y-0.609
Frac K+R+0.969
Frac D+E+0.433
Frac Polar-0.244
Frac Aliphatic-0.270
Frac Aromatic-1.123
R/K Ratio+1.093
E/D Ratio+1.665
Frac Chain Expanding+0.723
FCR+0.960
NCPR+0.310
Hydrophobicity-0.636
Disorder Promoting+1.668
Iso point+0.805
PPII-0.652
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+0.717
F Patch-0.012
G Patch+1.373
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch+1.969
S Patch+0.232
T Patch-0.147
V Patch+10.706
Y Patch-0.022
RG Frac+1.297
IDR 2 Cluster 27
Residues 353–383 · 30 aa (7.8% of protein) · Min inter-cluster distance: 2.142
P patches
Sequence
SNRTQGSLPFPSPSKPVEPLNPKKKDSPML
Top exceptional features (|z-score| rank)
P Patch: +4.72PPII: +1.77Frac P: +1.71Frac A: -1.42Frac K: +1.28hyd-pos: +1.26Disorder Promoting: -1.23Frac L: +1.18
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.230
pol-hyd+0.247
pol-pos-0.442
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.301
pol-gly+0.000
hyd-hyd+0.123
hyd-pos+1.258
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.692
hyd-gly+0.000
pos-pos+0.449
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.364
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.331
pro-gly+0.000
gly-gly+0.000
Frac A-1.420
Frac C-0.582
Frac D-0.432
Frac E-0.853
Frac F+1.078
Frac G-0.808
Frac H-0.849
Frac I-0.900
Frac K+1.285
Frac L+1.184
Frac M+0.883
Frac N+1.149
Frac P+1.706
Frac Q-0.469
Frac R-0.643
Frac S+0.624
Frac T-0.536
Frac V-0.093
Frac W-0.508
Frac Y-0.609
Frac K+R+0.528
Frac D+E-0.860
Frac Polar-0.485
Frac Aliphatic-0.642
Frac Aromatic+0.119
R/K Ratio-1.100
E/D Ratio-0.565
Frac Chain Expanding+0.865
FCR-0.301
NCPR+0.998
Hydrophobicity-0.068
Disorder Promoting-1.232
Iso point+0.939
PPII+1.770
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+4.721
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130