NephVar / Molecular Grammars / KANK2

KANK2 KANK2

SRNS panel · 851 aa · UniProt Q63ZY3 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 27
Residues 0–32 · 32 aa (3.8% of protein) · Min inter-cluster distance: 6.474
P patches
Sequence
MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPY
Top exceptional features (|z-score| rank)
P Patch: +5.44Frac P: +3.27PPII: +2.97Frac F: +2.73Frac Aromatic: +2.37hyd-hyd: +2.21E/D Ratio: -2.03Frac Polar: -1.92
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.651
pol-hyd-1.182
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala-0.531
pol-pro-0.242
pol-gly+0.000
hyd-hyd+2.209
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.694
hyd-pro+1.510
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala-0.918
ala-pro-0.833
ala-gly+0.000
pro-pro-0.139
pro-gly+0.000
gly-gly+0.000
Frac A+1.447
Frac C-0.582
Frac D+0.270
Frac E-1.354
Frac F+2.728
Frac G-0.337
Frac H+0.294
Frac I-0.900
Frac K-0.528
Frac L-0.786
Frac M+0.776
Frac N-0.989
Frac P+3.271
Frac Q-0.515
Frac R-1.304
Frac S-1.405
Frac T-0.583
Frac V+0.973
Frac W-0.508
Frac Y+1.242
Frac K+R-1.263
Frac D+E-0.908
Frac Polar-1.920
Frac Aliphatic+1.228
Frac Aromatic+2.370
R/K Ratio-0.864
E/D Ratio-2.028
Frac Chain Expanding+0.569
FCR-1.510
NCPR-0.145
Hydrophobicity+1.695
Disorder Promoting-0.371
Iso point-0.675
PPII+2.966
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+5.436
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 27
Residues 154–186 · 32 aa (3.8% of protein) · Min inter-cluster distance: 0.732
P patches
Sequence
STASLVGVGLPPPTPRSSGLSTPVPPSAGHLA
Top exceptional features (|z-score| rank)
Hydrophobicity: +2.78pro-gly: +2.23Frac V: +2.11FCR: -2.05Iso point: +1.98Frac L: +1.90Frac Aliphatic: +1.74hyd-pro: +1.64
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.549
pol-hyd+0.063
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.380
pol-gly-0.457
hyd-hyd-0.148
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+1.637
hyd-gly-1.279
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.389
pro-gly+2.233
gly-gly-0.330
Frac A+0.300
Frac C-0.582
Frac D-1.234
Frac E-1.354
Frac F-0.807
Frac G+0.674
Frac H+0.294
Frac I-0.900
Frac K-1.083
Frac L+1.900
Frac M-0.832
Frac N-0.989
Frac P+1.499
Frac Q-1.207
Frac R-0.685
Frac S+0.936
Frac T+0.820
Frac V+2.114
Frac W-0.508
Frac Y-0.609
Frac K+R-1.263
Frac D+E-1.627
Frac Polar+0.539
Frac Aliphatic+1.738
Frac Aromatic-1.123
R/K Ratio+0.598
E/D Ratio-0.565
Frac Chain Expanding-1.327
FCR-2.052
NCPR+0.399
Hydrophobicity+2.783
Disorder Promoting-0.371
Iso point+1.982
PPII+0.515
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.283
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 24
Residues 407–586 · 179 aa (21.0% of protein) · Min inter-cluster distance: 4.112
Weak negative charge
Sequence
TERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEI
Top exceptional features (|z-score| rank)
pol-neg: -1.64E/D Ratio: +1.44R/K Ratio: +0.95Iso point: -0.94Frac L: -0.88Frac E: +0.83hyd-ala: +0.79Disorder Promoting: +0.75
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.501
pol-hyd+0.443
pol-pos+0.000
pol-neg-1.643
pol-aro+0.000
pol-ala+0.635
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.214
hyd-pos+0.000
hyd-neg+0.187
hyd-aro+0.000
hyd-ala+0.790
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.131
neg-aro+0.000
neg-ala-0.071
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.704
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+0.630
Frac C+0.180
Frac D-0.562
Frac E+0.829
Frac F-0.491
Frac G+0.008
Frac H-0.236
Frac I+0.226
Frac K-0.686
Frac L-0.881
Frac M-0.544
Frac N-0.093
Frac P-0.257
Frac Q-0.094
Frac R+0.136
Frac S+0.219
Frac T+0.471
Frac V+0.526
Frac W-0.508
Frac Y-0.278
Frac K+R-0.420
Frac D+E+0.366
Frac Polar+0.247
Frac Aliphatic+0.194
Frac Aromatic-0.706
R/K Ratio+0.952
E/D Ratio+1.438
Frac Chain Expanding-0.183
FCR+0.000
NCPR-0.554
Hydrophobicity+0.121
Disorder Promoting+0.748
Iso point-0.944
PPII-0.197
A Patch+0.406
C Patch-0.009
D Patch-0.178
E Patch+0.379
F Patch-0.012
G Patch+0.050
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+0.213
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130