NephVar / Molecular Grammars / FAT1

FAT1 FAT1

SRNS panel · 4588 aa · UniProt Q14517 · 4 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 13
Residues 4297–4331 · 34 aa (0.7% of protein) · Min inter-cluster distance: 0.36
Blocks of negative, P, & polar residues
Sequence
AVAVCSVAPNLPPPPPSNSPSDSDSIQKPSWDFD
Top exceptional features (|z-score| rank)
neg-pro: +3.59E/D Ratio: -2.71S Patch: +2.51Frac W: +2.17P Patch: +2.16hyd-pro: +1.97Frac V: +1.91Frac P: +1.73
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.751
pol-hyd+0.467
pol-pos+0.000
pol-neg+0.101
pol-aro+0.000
pol-ala+0.000
pol-pro+1.093
pol-gly+0.000
hyd-hyd+0.442
hyd-pos+0.000
hyd-neg+0.771
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+1.969
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+1.251
neg-aro+0.000
neg-ala+0.000
neg-pro+3.592
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.891
pro-gly+0.000
gly-gly+0.000
Frac A+0.199
Frac C+1.424
Frac D+1.598
Frac E-1.354
Frac F+0.856
Frac G-1.347
Frac H-0.849
Frac I+0.583
Frac K-0.561
Frac L-0.838
Frac M-0.832
Frac N+0.898
Frac P+1.733
Frac Q-0.556
Frac R-1.304
Frac S+1.212
Frac T-1.284
Frac V+1.913
Frac W+2.168
Frac Y-0.609
Frac K+R-1.288
Frac D+E-0.273
Frac Polar-0.582
Frac Aliphatic+0.478
Frac Aromatic+1.069
R/K Ratio-0.864
E/D Ratio-2.708
Frac Chain Expanding+0.012
FCR-1.049
NCPR-0.641
Hydrophobicity+1.349
Disorder Promoting-1.725
Iso point-1.246
PPII+1.423
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+2.159
Q Patch-0.160
R Patch-0.247
S Patch+2.510
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 6
Residues 4340–4376 · 36 aa (0.8% of protein) · Min inter-cluster distance: 2.167
S patches
Sequence
PCLSKKPLEEKPSQPYSARESLSEVQSLSSFQSESC
Top exceptional features (|z-score| rank)
Frac C: +3.21S Patch: +2.34Frac S: +2.29E/D Ratio: +1.82Frac L: +1.50Frac G: -1.35Frac T: -1.28Frac D: -1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.925
pol-hyd-0.543
pol-pos+0.712
pol-neg-0.156
pol-aro+0.000
pol-ala+0.000
pol-pro+0.461
pol-gly+0.000
hyd-hyd-0.382
hyd-pos-0.437
hyd-neg-0.911
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.235
hyd-gly+0.000
pos-pos+0.359
pos-neg-0.498
pos-aro+0.000
pos-ala+0.000
pos-pro-1.228
pos-gly+0.000
neg-neg+0.078
neg-aro+0.000
neg-ala+0.000
neg-pro-0.310
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.145
pro-gly+0.000
gly-gly+0.000
Frac A-0.911
Frac C+3.207
Frac D-1.234
Frac E+0.733
Frac F+0.764
Frac G-1.347
Frac H-0.849
Frac I-0.900
Frac K+0.397
Frac L+1.502
Frac M-0.832
Frac N-0.989
Frac P-0.028
Frac Q+0.638
Frac R-0.754
Frac S+2.289
Frac T-1.284
Frac V-0.296
Frac W-0.508
Frac Y+1.036
Frac K+R-0.207
Frac D+E-0.028
Frac Polar+0.334
Frac Aliphatic-0.642
Frac Aromatic+0.947
R/K Ratio-0.864
E/D Ratio+1.822
Frac Chain Expanding-0.203
FCR-0.157
NCPR-0.115
Hydrophobicity+0.505
Disorder Promoting-0.933
Iso point-0.809
PPII+0.132
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+2.344
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 1
Residues 4433–4483 · 50 aa (1.1% of protein) · Min inter-cluster distance: 17.384
Blocks of P & polar residues
Sequence
DFPPPPEDFPAADELPPLPPEFSNQFESIHPPRDMPAAGSLGSSSRNRQR
Top exceptional features (|z-score| rank)
pol-pro: +4.75Frac F: +3.72pol-pol: +3.04pol-neg: +2.18Frac Aromatic: +1.86Frac P: +1.80pro-pro: +1.76R/K Ratio: +1.56
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+3.045
pol-hyd+0.000
pol-pos+0.000
pol-neg+2.180
pol-aro+0.000
pol-ala+0.000
pol-pro+4.751
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.107
neg-aro+0.000
neg-ala+0.000
neg-pro-0.349
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.760
pro-gly+0.000
gly-gly+0.000
Frac A+0.047
Frac C-0.582
Frac D+0.691
Frac E-0.152
Frac F+3.718
Frac G-0.701
Frac H-0.118
Frac I+0.108
Frac K-1.083
Frac L+0.038
Frac M+0.197
Frac N+0.294
Frac P+1.800
Frac Q-0.321
Frac R+0.282
Frac S-0.075
Frac T-1.284
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R-0.619
Frac D+E+0.214
Frac Polar-1.207
Frac Aliphatic-0.424
Frac Aromatic+1.858
R/K Ratio+1.564
E/D Ratio-0.565
Frac Chain Expanding+0.999
FCR-0.244
NCPR-0.569
Hydrophobicity+0.116
Disorder Promoting-0.394
Iso point-0.977
PPII+1.368
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.546
Q Patch-0.160
R Patch-0.247
S Patch+0.875
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 4 Cluster 28
Residues 4494–4525 · 31 aa (0.7% of protein) · Min inter-cluster distance: 9.195
High aromatic fraction, specifically Ys
Sequence
PLDMSEPQTKGTGENSTCREPHAPYPPGYQR
Top exceptional features (|z-score| rank)
Frac Y: +3.21P Patch: +2.05Frac Aliphatic: -1.78pol-pro: +1.77Frac C: +1.62Frac V: -1.31Frac Aromatic: +1.28Frac P: +1.14
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.077
pol-hyd+0.000
pol-pos+0.000
pol-neg-0.704
pol-aro+0.000
pol-ala+0.000
pol-pro+1.766
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.726
neg-aro+0.000
neg-ala+0.000
neg-pro+0.619
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.583
pro-gly+0.000
gly-gly+0.000
Frac A-0.829
Frac C+1.618
Frac D-0.458
Frac E+0.100
Frac F-0.807
Frac G+0.217
Frac H+0.331
Frac I-0.900
Frac K-0.510
Frac L-0.757
Frac M+0.828
Frac N+0.046
Frac P+1.141
Frac Q+0.222
Frac R-0.025
Frac S-0.907
Frac T+0.887
Frac V-1.311
Frac W-0.508
Frac Y+3.212
Frac K+R-0.397
Frac D+E-0.142
Frac Polar+0.361
Frac Aliphatic-1.782
Frac Aromatic+1.281
R/K Ratio+0.294
E/D Ratio+0.358
Frac Chain Expanding+0.386
FCR-0.367
NCPR-0.154
Hydrophobicity-0.986
Disorder Promoting+0.082
Iso point-0.675
PPII+0.949
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+2.054
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130