NephVar / Molecular Grammars / CD2AP

CD2AP CD2AP

SRNS panel · 639 aa · UniProt Q9Y5K6 · 4 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 24
Residues 165–210 · 45 aa (7.0% of protein) · Min inter-cluster distance: 4.892
Weak negative charge
Sequence
EVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKK
Top exceptional features (|z-score| rank)
neg-neg: +2.25Frac V: +1.94hyd-neg: +1.82Frac T: +1.71pol-pol: -1.36Frac R: -1.30R/K Ratio: -1.29NCPR: -1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.360
pol-hyd-0.786
pol-pos+0.000
pol-neg-0.213
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.227
hyd-pos+0.000
hyd-neg+1.820
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+2.254
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.197
Frac C-0.582
Frac D+0.905
Frac E+0.316
Frac F-0.807
Frac G+0.090
Frac H-0.036
Frac I+0.220
Frac K-0.294
Frac L-0.408
Frac M-0.832
Frac N-0.276
Frac P-0.343
Frac Q-0.223
Frac R-1.304
Frac S+0.125
Frac T+1.708
Frac V+1.937
Frac W-0.508
Frac Y-0.609
Frac K+R-1.089
Frac D+E+0.675
Frac Polar+0.608
Frac Aliphatic+0.265
Frac Aromatic-1.123
R/K Ratio-1.292
E/D Ratio-0.322
Frac Chain Expanding-0.484
FCR-0.205
NCPR-1.227
Hydrophobicity+0.648
Disorder Promoting+0.365
Iso point-1.145
PPII-0.382
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 25
Residues 221–265 · 44 aa (6.9% of protein) · Min inter-cluster distance: 0.535
Blocks of positive residues
Sequence
EGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTE
Top exceptional features (|z-score| rank)
Frac T: +2.29hyd-neg: +1.83Frac A: -1.42Frac I: +1.39Frac K: +1.34E/D Ratio: +1.28neg-neg: +1.21pol-hyd: +1.20
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.970
pol-hyd+1.202
pol-pos+0.566
pol-neg+0.469
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+1.182
hyd-pos+0.925
hyd-neg+1.828
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.371
pos-neg-0.125
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+1.214
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-1.420
Frac C-0.582
Frac D-0.687
Frac E+1.037
Frac F-0.807
Frac G-0.612
Frac H-0.849
Frac I+1.391
Frac K+1.339
Frac L+0.923
Frac M-0.832
Frac N-0.989
Frac P-0.637
Frac Q-0.201
Frac R-0.403
Frac S+0.170
Frac T+2.285
Frac V+0.350
Frac W-0.508
Frac Y-0.609
Frac K+R+0.728
Frac D+E+0.466
Frac Polar+0.036
Frac Aliphatic-0.394
Frac Aromatic-1.123
R/K Ratio-1.027
E/D Ratio+1.282
Frac Chain Expanding+0.512
FCR+0.827
NCPR+0.127
Hydrophobicity-0.109
Disorder Promoting+0.292
Iso point-0.137
PPII+0.039
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 1
Residues 327–462 · 135 aa (21.1% of protein) · Min inter-cluster distance: 12.045
Blocks of P & polar residues
Sequence
INELDKDFPKPKKPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFD
Top exceptional features (|z-score| rank)
pol-pro: +4.14neg-pro: +4.11pro-pro: +2.81P Patch: +2.75PPII: +2.12hyd-pro: +2.04R/K Ratio: -2.02Frac K: +1.94
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.245
pol-hyd-1.751
pol-pos+0.334
pol-neg+0.802
pol-aro+0.000
pol-ala+0.000
pol-pro+4.144
pol-gly+0.000
hyd-hyd-0.229
hyd-pos-0.257
hyd-neg-0.544
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+2.044
hyd-gly+0.000
pos-pos-1.667
pos-neg-0.712
pos-aro+0.000
pos-ala+0.000
pos-pro-0.235
pos-gly+0.000
neg-neg+1.187
neg-aro+0.000
neg-ala+0.000
neg-pro+4.105
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+2.812
pro-gly+0.000
gly-gly+0.000
Frac A-0.197
Frac C-0.582
Frac D-0.164
Frac E-0.018
Frac F+0.869
Frac G-1.108
Frac H-0.849
Frac I+0.967
Frac K+1.943
Frac L+0.441
Frac M-0.832
Frac N-0.276
Frac P+1.443
Frac Q-0.715
Frac R-0.864
Frac S-0.431
Frac T-0.453
Frac V+0.313
Frac W-0.508
Frac Y+0.269
Frac K+R+0.871
Frac D+E-0.092
Frac Polar-1.870
Frac Aliphatic+0.265
Frac Aromatic+0.533
R/K Ratio-2.023
E/D Ratio+0.260
Frac Chain Expanding+1.614
FCR+0.501
NCPR+0.643
Hydrophobicity+0.149
Disorder Promoting-0.434
Iso point+0.670
PPII+2.121
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+2.752
Q Patch-0.160
R Patch-0.247
S Patch-0.063
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 4 Cluster 16
Residues 487–538 · 51 aa (8.0% of protein) · Min inter-cluster distance: 13.281
Blocks of polar residues
Sequence
HLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKD
Top exceptional features (|z-score| rank)
pol-pos: +2.11hyd-pos: -2.10pol-hyd: +2.08pro-pro: -1.95pol-pol: +1.80Frac L: +1.69pol-neg: +1.69pos-pro: -1.59
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.803
pol-hyd+2.076
pol-pos+2.109
pol-neg+1.685
pol-aro+0.000
pol-ala+0.000
pol-pro-0.267
pol-gly+0.000
hyd-hyd-0.702
hyd-pos-2.098
hyd-neg+0.729
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.111
hyd-gly+0.000
pos-pos-0.241
pos-neg-0.057
pos-aro+0.000
pos-ala+0.000
pos-pro-1.586
pos-gly+0.000
neg-neg+1.177
neg-aro+0.000
neg-ala+0.000
neg-pro+0.504
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-1.945
pro-gly+0.000
gly-gly+0.000
Frac A-0.701
Frac C-0.582
Frac D-0.290
Frac E-0.175
Frac F+0.302
Frac G-0.079
Frac H+1.303
Frac I+0.088
Frac K+1.355
Frac L+1.689
Frac M+0.177
Frac N+0.898
Frac P+0.343
Frac Q-1.207
Frac R+0.251
Frac S-0.698
Frac T-0.404
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R+1.176
Frac D+E-0.273
Frac Polar-0.678
Frac Aliphatic-0.162
Frac Aromatic-0.392
R/K Ratio-0.629
E/D Ratio+0.116
Frac Chain Expanding+0.904
FCR+0.565
NCPR+0.981
Hydrophobicity-0.544
Disorder Promoting-0.668
Iso point+0.939
PPII+0.293
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130