NephVar / Molecular Grammars / CEP290

CEP290 CE290

NPHP panel · 2479 aa · UniProt O15078 · 1 IDR · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 19
Residues 130–171 · 41 aa (1.7% of protein) · Min inter-cluster distance: 4.829
High negative fraction, specifically Es
LEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKK
E Patch: +5.30Frac N: +2.92FCR: +2.75Frac E: +2.68Frac L: +2.51Frac K: +2.38Frac K+R: +2.19Disorder Promoting: -2.14
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.365
pol-hyd-0.325
pol-pos+0.431
pol-neg+0.077
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-0.749
hyd-pos-0.662
hyd-neg-0.287
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+1.097
pos-neg+0.714
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.037
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.525
Frac C-0.582
Frac D-0.647
Frac E+2.678
Frac F-0.807
Frac G-1.347
Frac H-0.849
Frac I-0.900
Frac K+2.382
Frac L+2.511
Frac M+0.423
Frac N+2.923
Frac P-1.604
Frac Q-0.667
Frac R+0.630
Frac S-1.508
Frac T-1.284
Frac V-0.420
Frac W-0.508
Frac Y-0.609
Frac K+R+2.195
Frac D+E+1.742
Frac Polar-2.085
Frac Aliphatic+0.618
Frac Aromatic-1.123
R/K Ratio-0.753
E/D Ratio+1.822
Frac Chain Expanding+2.065
FCR+2.748
NCPR+0.127
Hydrophobicity-1.916
Disorder Promoting-2.138
Iso point-0.137
PPII-0.310
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+5.296
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130