NephVar / Molecular Grammars / WT1

WT1 WT1

SRNS panel · 449 aa · UniProt P19544 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 1
Residues 44–85 · 41 aa (9.1% of protein) · Min inter-cluster distance: 17.119
Blocks of P & polar residues
Sequence
ASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHE
Top exceptional features (|z-score| rank)
pro-gly: +5.84pro-pro: +4.91pol-pro: +4.84P Patch: +3.60Frac P: +3.58PPII: +2.99ala-pro: +2.89gly-gly: +2.14
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.716
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.200
pol-pro+4.836
pol-gly+0.245
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala-0.306
ala-pro+2.893
ala-gly-0.355
pro-pro+4.905
pro-gly+5.837
gly-gly+2.137
Frac A+0.817
Frac C-0.582
Frac D-1.234
Frac E-0.254
Frac F+0.572
Frac G+0.625
Frac H+0.935
Frac I+0.329
Frac K-0.650
Frac L-0.982
Frac M-0.832
Frac N-0.989
Frac P+3.585
Frac Q-0.667
Frac R-1.304
Frac S-0.412
Frac T-1.284
Frac V-1.311
Frac W+1.711
Frac Y+0.836
Frac K+R-1.354
Frac D+E-0.785
Frac Polar-0.885
Frac Aliphatic-0.575
Frac Aromatic+1.604
R/K Ratio-0.864
E/D Ratio+1.282
Frac Chain Expanding+0.832
FCR-1.477
NCPR-0.297
Hydrophobicity+0.483
Disorder Promoting+1.368
Iso point-0.675
PPII+2.991
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+3.605
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 28
Residues 154–197 · 43 aa (9.6% of protein) · Min inter-cluster distance: 17.583
High aromatic fraction, specifically Ys
Sequence
DGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPP
Top exceptional features (|z-score| rank)
Frac H: +3.40Frac Aromatic: +2.34Frac Y: +2.15Frac F: +1.82Frac Polar: +1.50Frac Aliphatic: -1.46Frac K+R: -1.37Frac Q: +1.37
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.822
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-0.566
pol-gly-0.017
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.835
pro-gly-0.394
gly-gly+0.196
Frac A-0.567
Frac C-0.582
Frac D-0.115
Frac E-0.655
Frac F+1.823
Frac G+0.533
Frac H+3.405
Frac I-0.900
Frac K-0.670
Frac L-1.015
Frac M+0.365
Frac N-0.243
Frac P+0.375
Frac Q+1.368
Frac R-1.304
Frac S-0.131
Frac T-0.240
Frac V-0.461
Frac W-0.508
Frac Y+2.146
Frac K+R-1.369
Frac D+E-0.556
Frac Polar+1.497
Frac Aliphatic-1.464
Frac Aromatic+2.343
R/K Ratio-0.864
E/D Ratio-0.565
Frac Chain Expanding-1.268
FCR-1.315
NCPR-0.480
Hydrophobicity-0.437
Disorder Promoting+0.216
Iso point-0.338
PPII-0.199
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130