NephVar / Molecular Grammars / SRGAP1

SRGAP1 SRGP1

CAKUT panel · 1085 aa · UniProt Q7Z6B7 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 28
Residues 468–501 · 33 aa (3.0% of protein) · Min inter-cluster distance: 1.863
High aromatic fraction, specifically Ys
Sequence
EGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNT
Top exceptional features (|z-score| rank)
Frac Y: +2.98Hydrophobicity: -2.26P Patch: +2.24Frac Aliphatic: -1.88NCPR: +1.71Frac R: +1.70Frac L: -1.68Frac K+R: +1.53
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.486
pol-hyd+0.000
pol-pos-0.912
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-0.071
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.542
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.413
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.002
pro-gly+0.000
gly-gly+0.000
Frac A-0.864
Frac C-0.582
Frac D-1.234
Frac E-0.443
Frac F-0.807
Frac G-0.857
Frac H+1.368
Frac I-0.900
Frac K+0.532
Frac L-1.681
Frac M+0.727
Frac N+0.955
Frac P+0.975
Frac Q+0.135
Frac R+1.700
Frac S-0.965
Frac T+0.756
Frac V-0.204
Frac W-0.508
Frac Y+2.980
Frac K+R+1.530
Frac D+E-0.930
Frac Polar-0.187
Frac Aliphatic-1.878
Frac Aromatic+1.135
R/K Ratio+0.294
E/D Ratio+0.898
Frac Chain Expanding+1.048
FCR+0.302
NCPR+1.710
Hydrophobicity-2.262
Disorder Promoting+0.292
Iso point+1.343
PPII+1.418
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+2.238
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 25
Residues 805–959 · 154 aa (14.2% of protein) · Min inter-cluster distance: 6.386
Blocks of positive residues
Sequence
FSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRHPDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIA
Top exceptional features (|z-score| rank)
hyd-hyd: -2.02E/D Ratio: -1.69pol-pro: +1.68pol-hyd: -1.51pol-pos: +1.34pos-pro: +1.29Frac H: +1.05hyd-neg: -0.98
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.580
pol-hyd-1.513
pol-pos+1.342
pol-neg-0.630
pol-aro+0.000
pol-ala+0.000
pol-pro+1.676
pol-gly+0.000
hyd-hyd-2.017
hyd-pos+0.750
hyd-neg-0.977
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.885
hyd-gly+0.000
pos-pos+0.752
pos-neg+0.471
pos-aro+0.000
pos-ala+0.000
pos-pro+1.289
pos-gly+0.000
neg-neg-0.734
neg-aro+0.000
neg-ala+0.000
neg-pro-0.255
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.106
pro-gly+0.000
gly-gly+0.000
Frac A-0.706
Frac C-0.139
Frac D+0.798
Frac E-0.866
Frac F-0.073
Frac G-0.087
Frac H+1.051
Frac I+0.409
Frac K-0.276
Frac L+0.551
Frac M-0.498
Frac N+0.469
Frac P+0.146
Frac Q-0.632
Frac R+0.756
Frac S+0.462
Frac T-0.118
Frac V-0.599
Frac W-0.508
Frac Y+0.160
Frac K+R+0.299
Frac D+E-0.282
Frac Polar+0.324
Frac Aliphatic-0.606
Frac Aromatic-0.155
R/K Ratio+0.661
E/D Ratio-1.693
Frac Chain Expanding+0.085
FCR-0.016
NCPR+0.410
Hydrophobicity-0.346
Disorder Promoting-0.174
Iso point+0.805
PPII-0.339
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.159
Q Patch-0.160
R Patch+0.360
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 16
Residues 968–1085 · 117 aa (10.8% of protein) · Min inter-cluster distance: 1.691
Blocks of polar residues
Sequence
ALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTDKSCTM
Top exceptional features (|z-score| rank)
pol-pol: +2.75pol-pro: +2.27pol-hyd: +1.90pos-pos: -1.52Frac Aliphatic: +1.24hyd-pos: -1.09Disorder Promoting: -1.05Hydrophobicity: +1.04
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+2.755
pol-hyd+1.904
pol-pos+0.638
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+2.273
pol-gly+0.000
hyd-hyd+0.634
hyd-pos-1.090
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.497
hyd-gly+0.000
pos-pos-1.522
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.064
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.607
pro-gly+0.000
gly-gly+0.000
Frac A-0.009
Frac C+0.001
Frac D-0.411
Frac E-0.583
Frac F-0.324
Frac G-0.933
Frac H-0.224
Frac I-0.038
Frac K-0.020
Frac L+1.012
Frac M+0.927
Frac N+0.107
Frac P+0.578
Frac Q-0.261
Frac R-0.118
Frac S-0.080
Frac T+1.017
Frac V+0.875
Frac W-0.508
Frac Y-0.609
Frac K+R-0.094
Frac D+E-0.643
Frac Polar-0.317
Frac Aliphatic+1.241
Frac Aromatic-0.804
R/K Ratio-0.133
E/D Ratio-0.117
Frac Chain Expanding-0.225
FCR-0.546
NCPR+0.425
Hydrophobicity+1.038
Disorder Promoting-1.048
Iso point+0.738
PPII+0.714
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.310
Q Patch-0.160
R Patch-0.247
S Patch+0.098
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130