NephVar / Molecular Grammars / LAMB2

LAMB2 LAMC1

SRNS panel · 1609 aa · UniProt P11047 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 17
Residues 1400–1447 · 47 aa (2.9% of protein) · Min inter-cluster distance: 2.71
Weak positive charge
Sequence
ANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEA
Top exceptional features (|z-score| rank)
Frac A: +4.43A Patch: +3.14Frac Aliphatic: +2.89Frac P: -1.60neg-ala: -1.29Disorder Promoting: +1.26pol-pos: -1.26pol-pol: -1.21
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.212
pol-hyd+0.000
pol-pos-1.264
pol-neg+0.195
pol-aro+0.000
pol-ala-1.111
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.645
pos-neg-1.001
pos-aro+0.000
pos-ala-0.187
pos-pro+0.000
pos-gly+0.000
neg-neg+0.029
neg-aro+0.000
neg-ala-1.286
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala-1.171
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+4.435
Frac C-0.582
Frac D-0.722
Frac E+0.565
Frac F-0.807
Frac G-1.003
Frac H-0.071
Frac I+0.172
Frac K+0.806
Frac L-1.071
Frac M-0.832
Frac N+1.058
Frac P-1.604
Frac Q+0.206
Frac R-0.461
Frac S-0.917
Frac T+0.626
Frac V-0.534
Frac W-0.508
Frac Y-0.609
Frac K+R+0.293
Frac D+E+0.087
Frac Polar-0.625
Frac Aliphatic+2.888
Frac Aromatic-1.123
R/K Ratio-0.864
E/D Ratio+1.104
Frac Chain Expanding-0.843
FCR+0.258
NCPR+0.127
Hydrophobicity+0.367
Disorder Promoting+1.265
Iso point-0.137
PPII-0.586
A Patch+3.139
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 9
Residues 1471–1504 · 33 aa (2.1% of protein) · Min inter-cluster distance: 1.377
Blocks of positive & negative residues
Sequence
EKELKRKQDDADQDMMMAGMASQAAQEAEINAR
Top exceptional features (|z-score| rank)
M Patch: +50.60A Patch: +6.40D Patch: +5.54Frac M: +5.41Frac Aliphatic: +3.07pos-ala: +2.92pos-pos: +2.75Frac A: +2.47
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.046
pol-hyd+1.026
pol-pos+1.281
pol-neg-0.557
pol-aro+0.000
pol-ala-1.372
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.330
hyd-pos+1.662
hyd-neg+1.026
hyd-aro+0.000
hyd-ala+0.538
hyd-pro+0.000
hyd-gly+0.000
pos-pos+2.754
pos-neg+0.791
pos-aro+0.000
pos-ala+2.921
pos-pro+0.000
pos-gly+0.000
neg-neg+0.946
neg-aro+0.000
neg-ala+0.069
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.050
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+2.472
Frac C-0.582
Frac D+1.684
Frac E+0.468
Frac F-0.807
Frac G-0.857
Frac H-0.849
Frac I+0.628
Frac K+0.532
Frac L-0.813
Frac M+5.405
Frac N-0.017
Frac P-1.604
Frac Q+1.477
Frac R-0.103
Frac S-1.420
Frac T-1.284
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R+0.327
Frac D+E+1.163
Frac Polar-1.678
Frac Aliphatic+3.066
Frac Aromatic-1.123
R/K Ratio-0.437
E/D Ratio-0.565
Frac Chain Expanding+0.129
FCR+1.090
NCPR-0.664
Hydrophobicity-0.197
Disorder Promoting-0.252
Iso point-0.977
PPII-0.381
A Patch+6.401
C Patch-0.009
D Patch+5.538
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch+50.596
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130