NephVar / Molecular Grammars / SDCCAG8

SDCCAG8 SDCG8

NPHP panel · 713 aa · UniProt Q86SQ7 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 9
Residues 74–115 · 41 aa (5.8% of protein) · Min inter-cluster distance: 1.928
Blocks of positive & negative residues
Sequence
NQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTM
Top exceptional features (|z-score| rank)
Frac M: +2.93pos-neg: +2.15Frac L: +1.81Frac G: -1.35Disorder Promoting: -1.26pol-neg: -1.16Frac Aromatic: -1.12Frac R: +1.11
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.709
pol-hyd-0.819
pol-pos+0.053
pol-neg-1.158
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-0.026
hyd-pos-0.227
hyd-neg+0.190
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.530
pos-neg+2.155
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.696
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.973
Frac C-0.582
Frac D-0.060
Frac E+0.479
Frac F-0.807
Frac G-1.347
Frac H+0.043
Frac I-0.900
Frac K+0.217
Frac L+1.813
Frac M+2.933
Frac N+0.576
Frac P-0.566
Frac Q+0.413
Frac R+1.114
Frac S-0.046
Frac T-0.189
Frac V-0.420
Frac W-0.508
Frac Y-0.609
Frac K+R+0.904
Frac D+E+0.338
Frac Polar-0.645
Frac Aliphatic+0.618
Frac Aromatic-1.123
R/K Ratio+0.294
E/D Ratio+0.358
Frac Chain Expanding+0.585
FCR+0.846
NCPR+0.339
Hydrophobicity-0.762
Disorder Promoting-1.261
Iso point+0.670
PPII-0.047
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 4
Residues 182–218 · 36 aa (5.0% of protein) · Min inter-cluster distance: 0.305
Weak negative charge, high N fraction
Sequence
GNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAAS
Top exceptional features (|z-score| rank)
Frac F: +2.33Frac W: +2.02PPII: -1.99Frac Aromatic: +1.98Frac N: +1.68Frac L: -1.68Frac Chain Expanding: -1.33neg-gly: -1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.002
pol-hyd+0.000
pol-pos+0.000
pol-neg-0.160
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.282
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.092
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly-1.227
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.091
Frac A+0.109
Frac C-0.582
Frac D+0.772
Frac E-0.519
Frac F+2.335
Frac G+0.898
Frac H+1.183
Frac I+0.500
Frac K-0.096
Frac L-1.681
Frac M+0.597
Frac N+1.684
Frac P-1.210
Frac Q-1.207
Frac R-0.754
Frac S+0.208
Frac T+0.586
Frac V-0.296
Frac W+2.019
Frac Y-0.609
Frac K+R-0.574
Frac D+E-0.028
Frac Polar+1.154
Frac Aliphatic-0.642
Frac Aromatic+1.982
R/K Ratio-0.561
E/D Ratio-0.948
Frac Chain Expanding-1.327
FCR-0.398
NCPR-0.356
Hydrophobicity+0.213
Disorder Promoting-0.933
Iso point-0.675
PPII-1.989
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 17
Residues 531–568 · 37 aa (5.2% of protein) · Min inter-cluster distance: 0.645
Weak positive charge
Sequence
EHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELT
Top exceptional features (|z-score| rank)
Q Patch: +7.20Frac Q: +4.18A Patch: +4.06ala-ala: +2.17Frac P: -1.60pos-neg: -1.56Frac L: +1.42Frac G: -1.35
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.436
pol-hyd-1.288
pol-pos-0.183
pol-neg+0.148
pol-aro+0.000
pol-ala+0.090
pol-pro+0.000
pol-gly+0.000
hyd-hyd-0.332
hyd-pos+0.412
hyd-neg+0.018
hyd-aro+0.000
hyd-ala+0.674
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.749
pos-neg-1.561
pos-aro+0.000
pos-ala-0.049
pos-pro+0.000
pos-gly+0.000
neg-neg+0.612
neg-aro+0.000
neg-ala+1.248
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+2.166
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+0.563
Frac C-0.582
Frac D-0.584
Frac E+0.677
Frac F+0.721
Frac G-1.347
Frac H+1.128
Frac I+0.462
Frac K+0.357
Frac L+1.416
Frac M-0.832
Frac N-0.989
Frac P-1.604
Frac Q+4.180
Frac R-0.233
Frac S-0.659
Frac T-0.071
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R+0.111
Frac D+E+0.239
Frac Polar+0.489
Frac Aliphatic+0.608
Frac Aromatic-0.116
R/K Ratio-0.437
E/D Ratio+0.898
Frac Chain Expanding-0.849
FCR+0.253
NCPR-0.108
Hydrophobicity-0.794
Disorder Promoting+0.645
Iso point-0.271
PPII-0.333
A Patch+4.059
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch+7.197
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130