NephVar / Molecular Grammars / SIX5

SIX5 SIX5

CAKUT panel · 739 aa · UniProt Q8N196 · 4 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 8
Residues 0–84 · 84 aa (11.4% of protein) · Min inter-cluster distance: 17.881
Blocks of negative & A residues
Sequence
MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGL
Top exceptional features (|z-score| rank)
A Patch: +5.21Frac A: +4.70ala-pro: +4.16Frac Aliphatic: +3.63neg-ala: +3.56pol-ala: +3.54neg-pro: +3.17ala-ala: +3.06
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.511
pol-hyd+0.000
pol-pos+0.000
pol-neg+2.050
pol-aro+0.000
pol-ala+3.543
pol-pro-0.809
pol-gly+1.276
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.615
neg-aro+0.000
neg-ala+3.558
neg-pro+3.166
neg-gly+2.869
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+3.060
ala-pro+4.157
ala-gly+0.733
pro-pro+2.333
pro-gly-0.439
gly-gly+1.370
Frac A+4.696
Frac C-0.582
Frac D-1.234
Frac E+0.972
Frac F-0.807
Frac G+1.155
Frac H-0.849
Frac I-0.900
Frac K-1.083
Frac L+0.024
Frac M-0.219
Frac N-0.989
Frac P+0.085
Frac Q-0.416
Frac R-1.068
Frac S-1.160
Frac T-0.215
Frac V-0.441
Frac W-0.508
Frac Y-0.609
Frac K+R-1.519
Frac D+E+0.154
Frac Polar-0.954
Frac Aliphatic+3.631
Frac Aromatic-1.123
R/K Ratio+0.598
E/D Ratio+2.950
Frac Chain Expanding-0.966
FCR-0.879
NCPR-1.116
Hydrophobicity+2.178
Disorder Promoting+1.848
Iso point-1.347
PPII+0.021
A Patch+5.211
C Patch-0.009
D Patch-0.178
E Patch+0.684
F Patch-0.012
G Patch+1.323
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.003
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 0
Residues 244–298 · 54 aa (7.3% of protein) · Min inter-cluster distance: 9.798
Blocks of G & polar residues
Sequence
VSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEA
Top exceptional features (|z-score| rank)
pos-gly: +3.16neg-gly: +2.85R Patch: +2.35neg-ala: +2.10pos-ala: +1.92ala-ala: +1.49ala-gly: -1.31pol-gly: +1.25
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.245
pol-hyd+0.000
pol-pos-0.857
pol-neg-0.489
pol-aro+0.000
pol-ala+1.099
pol-pro+0.000
pol-gly+1.251
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.333
pos-neg+1.152
pos-aro+0.000
pos-ala+1.919
pos-pro+0.000
pos-gly+3.163
neg-neg+1.086
neg-aro+0.000
neg-ala+2.096
neg-pro+0.000
neg-gly+2.854
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+1.487
ala-pro+0.000
ala-gly-1.315
pro-pro+0.000
pro-gly+0.000
gly-gly+0.626
Frac A+0.618
Frac C+0.681
Frac D+0.549
Frac E+0.316
Frac F+0.240
Frac G+0.449
Frac H-0.849
Frac I-0.900
Frac K-0.425
Frac L-1.150
Frac M-0.832
Frac N+0.793
Frac P-0.553
Frac Q-0.797
Frac R+0.899
Frac S+0.069
Frac T-0.037
Frac V+0.042
Frac W+1.177
Frac Y-0.609
Frac K+R+0.283
Frac D+E+0.504
Frac Polar+0.061
Frac Aliphatic-0.642
Frac Aromatic+0.257
R/K Ratio+0.760
E/D Ratio-0.117
Frac Chain Expanding+0.265
FCR+0.565
NCPR-0.195
Hydrophobicity-0.572
Disorder Promoting+0.564
Iso point-0.876
PPII-0.786
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+0.766
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch+2.352
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 2
Residues 355–418 · 63 aa (8.5% of protein) · Min inter-cluster distance: 7.938
Blocks of negative, P, & G residues
Sequence
LGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALG
Top exceptional features (|z-score| rank)
L Patch: +7.71hyd-hyd: +2.31neg-pro: +2.19hyd-pro: +2.17neg-gly: +2.10Frac L: +1.96hyd-ala: +1.81Hydrophobicity: +1.56
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.189
pol-hyd+1.407
pol-pos+0.000
pol-neg-0.652
pol-aro+0.000
pol-ala+0.240
pol-pro+0.582
pol-gly+1.189
hyd-hyd+2.315
hyd-pos+0.000
hyd-neg+0.664
hyd-aro+0.000
hyd-ala+1.807
hyd-pro+2.169
hyd-gly+1.376
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.770
neg-aro+0.000
neg-ala-0.062
neg-pro+2.188
neg-gly+2.096
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.001
ala-pro+0.348
ala-gly-0.102
pro-pro+0.961
pro-gly+1.323
gly-gly+0.333
Frac A+0.910
Frac C-0.582
Frac D-0.852
Frac E+0.077
Frac F-0.807
Frac G+1.219
Frac H-0.849
Frac I-0.900
Frac K-0.519
Frac L+1.957
Frac M-0.832
Frac N-0.989
Frac P+0.647
Frac Q+0.550
Frac R-0.990
Frac S-0.922
Frac T+0.497
Frac V+0.429
Frac W-0.508
Frac Y-0.609
Frac K+R-1.047
Frac D+E-0.348
Frac Polar-0.017
Frac Aliphatic+1.560
Frac Aromatic-1.123
R/K Ratio-0.561
E/D Ratio+1.104
Frac Chain Expanding-0.645
FCR-0.947
NCPR-0.426
Hydrophobicity+1.565
Disorder Promoting+0.422
Iso point-1.078
PPII+0.459
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+0.444
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch+7.714
M Patch-0.026
N Patch-0.076
P Patch+0.783
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 4 Cluster 1
Residues 595–652 · 57 aa (7.7% of protein) · Min inter-cluster distance: 3.249
Blocks of P & polar residues
Sequence
PEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPP
Top exceptional features (|z-score| rank)
P Patch: +2.86Frac P: +2.38Hydrophobicity: +2.11pol-pro: +2.06FCR: -1.87Frac L: +1.84PPII: +1.75Frac K+R: -1.68
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.856
pol-hyd+1.310
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+1.221
pol-pro+2.065
pol-gly+0.000
hyd-hyd-0.098
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.758
hyd-pro-0.084
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.191
ala-pro-0.839
ala-gly+0.000
pro-pro+1.281
pro-gly+0.000
gly-gly+0.000
Frac A+1.477
Frac C-0.582
Frac D-0.812
Frac E-0.826
Frac F+1.177
Frac G-0.213
Frac H-0.207
Frac I-0.900
Frac K-1.083
Frac L+1.837
Frac M-0.832
Frac N-0.426
Frac P+2.377
Frac Q-0.430
Frac R-1.304
Frac S-0.033
Frac T+0.291
Frac V-0.670
Frac W-0.508
Frac Y-0.609
Frac K+R-1.677
Frac D+E-1.021
Frac Polar-0.485
Frac Aliphatic+1.505
Frac Aromatic+0.185
R/K Ratio-0.133
E/D Ratio-0.025
Frac Chain Expanding-0.484
FCR-1.866
NCPR-0.331
Hydrophobicity+2.109
Disorder Promoting+0.092
Iso point-1.145
PPII+1.755
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+2.856
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130