NephVar / Molecular Grammars / MYH9

MYH9 MYH9

SRNS panel · 1960 aa · UniProt P35579 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 19
Residues 1113–1167 · 54 aa (2.8% of protein) · Min inter-cluster distance: 12.793
High negative fraction, specifically Es
Sequence
SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ
Top exceptional features (|z-score| rank)
Frac L: +2.56hyd-neg: -2.32E Patch: +2.06Frac E: +1.99FCR: +1.85pos-pos: +1.84Frac D+E: +1.78Frac P: -1.60
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.730
pol-hyd-0.612
pol-pos-0.562
pol-neg-0.375
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-1.017
hyd-pos+1.102
hyd-neg-2.322
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+1.840
pos-neg+1.184
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.579
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+0.279
Frac C-0.582
Frac D+0.549
Frac E+1.986
Frac F-0.807
Frac G-1.048
Frac H-0.849
Frac I-0.900
Frac K+0.561
Frac L+2.563
Frac M-0.832
Frac N-0.395
Frac P-1.604
Frac Q+0.843
Frac R+0.532
Frac S-0.486
Frac T-0.037
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R+0.773
Frac D+E+1.783
Frac Polar-1.032
Frac Aliphatic+0.567
Frac Aromatic-1.123
R/K Ratio-0.133
E/D Ratio+0.708
Frac Chain Expanding+1.014
FCR+1.848
NCPR-0.840
Hydrophobicity-1.108
Disorder Promoting+0.564
Iso point-0.977
PPII-0.736
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+2.062
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 9
Residues 1850–1960 · 110 aa (5.6% of protein) · Min inter-cluster distance: 5.819
Blocks of positive & negative residues
Sequence
VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE
Top exceptional features (|z-score| rank)
pos-neg: +2.80hyd-pos: -1.66hyd-ala: +1.66neg-neg: +1.66Frac Polar: -1.62FCR: +1.61A Patch: +1.37pol-pos: -1.25
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.106
pol-hyd-0.591
pol-pos-1.253
pol-neg+0.694
pol-aro+0.000
pol-ala-0.694
pol-pro+0.000
pol-gly+0.000
hyd-hyd-0.072
hyd-pos-1.662
hyd-neg+0.907
hyd-aro+0.000
hyd-ala+1.662
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.238
pos-neg+2.796
pos-aro+0.000
pos-ala+0.335
pos-pro+0.000
pos-gly+0.000
neg-neg+1.661
neg-aro+0.000
neg-ala-0.613
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.671
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+1.248
Frac C-0.582
Frac D+1.173
Frac E+0.695
Frac F-0.293
Frac G-0.465
Frac H-0.849
Frac I-0.900
Frac K+0.532
Frac L+0.402
Frac M+0.104
Frac N+0.177
Frac P-1.217
Frac Q+0.001
Frac R+1.220
Frac S-1.192
Frac T-0.672
Frac V+0.350
Frac W-0.508
Frac Y-0.070
Frac K+R+1.209
Frac D+E+1.093
Frac Polar-1.618
Frac Aliphatic+1.237
Frac Aromatic-0.445
R/K Ratio+0.194
E/D Ratio-0.182
Frac Chain Expanding+1.018
FCR+1.615
NCPR-0.031
Hydrophobicity-0.718
Disorder Promoting+0.129
Iso point-0.675
PPII-0.535
A Patch+1.372
C Patch-0.009
D Patch-0.178
E Patch+0.440
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130