NephVar / Molecular Grammars / NPHP1

NPHP1 NPHP1

NPHP panel · 732 aa · UniProt O15259 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 7
Residues 102–156 · 54 aa (7.4% of protein) · Min inter-cluster distance: 23.668
D/E-tracts
Sequence
ISRENITEVGAPTEEEEESESEDSEDSGGEEEDAEEEEEEKEENESHKWSTGEE
Top exceptional features (|z-score| rank)
E Patch: +7.15Frac E: +5.33Frac D+E: +4.13NCPR: -3.74FCR: +2.49neg-neg: +2.17Hydrophobicity: -2.16Frac Chain Expanding: +1.95
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.689
pol-hyd+0.000
pol-pos+0.000
pol-neg+1.843
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+2.174
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.741
Frac C-0.582
Frac D+0.103
Frac E+5.325
Frac F-0.807
Frac G-0.150
Frac H-0.172
Frac I+0.967
Frac K-0.425
Frac L-1.681
Frac M-0.832
Frac N+0.199
Frac P-1.341
Frac Q-1.207
Frac R-0.937
Frac S+0.069
Frac T-0.037
Frac V-0.634
Frac W+1.177
Frac Y-0.609
Frac K+R-0.942
Frac D+E+4.128
Frac Polar-0.668
Frac Aliphatic-1.850
Frac Aromatic-0.433
R/K Ratio-0.561
E/D Ratio+1.876
Frac Chain Expanding+1.951
FCR+2.490
NCPR-3.742
Hydrophobicity-2.159
Disorder Promoting+1.563
Iso point-1.280
PPII-0.882
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+7.151
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.402
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 19
Residues 197–244 · 47 aa (6.4% of protein) · Min inter-cluster distance: 3.325
High negative fraction, specifically Es
Sequence
NEGLVPRTYLEPYSEEEEGQESSEEGSEEDVEAVDETADGAEVKQRT
Top exceptional features (|z-score| rank)
E Patch: +5.19Frac E: +3.12Frac D+E: +2.54NCPR: -2.47Frac Y: +1.91Frac V: +1.80FCR: +1.36Iso point: -1.25
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.328
pol-hyd+0.097
pol-pos+0.000
pol-neg-0.330
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.086
hyd-pos+0.000
hyd-neg+0.817
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.278
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.249
Frac C-0.582
Frac D+0.302
Frac E+3.122
Frac F-0.807
Frac G+0.029
Frac H-0.849
Frac I-0.900
Frac K-0.705
Frac L-0.462
Frac M-0.832
Frac N-0.307
Frac P-1.000
Frac Q-0.265
Frac R-0.461
Frac S-0.598
Frac T+0.148
Frac V+1.799
Frac W-0.508
Frac Y+1.911
Frac K+R-0.832
Frac D+E+2.536
Frac Polar-0.834
Frac Aliphatic-0.237
Frac Aromatic+0.463
R/K Ratio+0.294
E/D Ratio+1.196
Frac Chain Expanding+0.879
FCR+1.363
NCPR-2.466
Hydrophobicity-0.682
Disorder Promoting+0.119
Iso point-1.246
PPII-0.656
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+5.190
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130