NephVar / Molecular Grammars / BMP4

BMP4 BMP4

CAKUT panel · 408 aa · UniProt P12644 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 7
Residues 89–128 · 39 aa (9.6% of protein) · Min inter-cluster distance: 1.304
D/E-tracts
Sequence
QSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLEN
Top exceptional features (|z-score| rank)
Frac H: +2.90E/D Ratio: +2.63Frac E: +2.50neg-neg: +2.29pol-neg: +1.87hyd-neg: +1.57E Patch: +1.51NCPR: -1.44
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.397
pol-hyd-1.343
pol-pos+0.000
pol-neg+1.867
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-1.294
hyd-pos+0.000
hyd-neg+1.570
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+2.289
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.479
Frac C-0.582
Frac D-1.234
Frac E+2.499
Frac F+0.643
Frac G-0.518
Frac H+2.903
Frac I+0.392
Frac K-1.083
Frac L-0.212
Frac M-0.832
Frac N+0.656
Frac P-0.876
Frac Q-0.072
Frac R+0.221
Frac S-0.337
Frac T-0.133
Frac V-0.374
Frac W-0.508
Frac Y+0.910
Frac K+R-0.659
Frac D+E+1.324
Frac Polar+0.271
Frac Aliphatic-0.851
Frac Aromatic+0.788
R/K Ratio+1.328
E/D Ratio+2.629
Frac Chain Expanding+0.035
FCR+0.565
NCPR-1.435
Hydrophobicity-1.126
Disorder Promoting-0.126
Iso point-0.910
PPII-0.931
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+1.506
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 26
Residues 278–308 · 30 aa (7.4% of protein) · Min inter-cluster distance: 33.1
R patches
Sequence
GRGHALTRRRRAKRSPKHHSQRARKKNKNC
Top exceptional features (|z-score| rank)
R Patch: +5.21Frac K+R: +4.05Frac R: +3.98NCPR: +3.90Frac H: +2.81Hydrophobicity: -2.62Frac K: +1.88Iso point: +1.81
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.620
pol-hyd+0.000
pol-pos+0.916
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.220
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+0.414
Frac C+1.691
Frac D-1.234
Frac E-1.354
Frac F-0.807
Frac G-0.269
Frac H+2.810
Frac I-0.900
Frac K+1.877
Frac L-0.726
Frac M-0.832
Frac N+1.149
Frac P-1.131
Frac Q-0.469
Frac R+3.984
Frac S-0.875
Frac T-0.536
Frac V-1.311
Frac W-0.508
Frac Y-0.609
Frac K+R+4.055
Frac D+E-1.627
Frac Polar+0.170
Frac Aliphatic-1.185
Frac Aromatic-1.123
R/K Ratio+0.294
E/D Ratio-0.565
Frac Chain Expanding+0.865
FCR+1.431
NCPR+3.899
Hydrophobicity-2.625
Disorder Promoting+1.163
Iso point+1.814
PPII-0.665
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch+5.212
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130