COL4A3 CO4A3
IDR map — colored by GIN molecular grammar cluster
IDR 1
Cluster 22
Residues 43–115 · 72 aa
(4.3% of protein) · Min inter-cluster distance: 29.955
Well-mixed P and G
Sequence
A K G E K G E K G F P G PP G S P G Q K G F T G P E G L P G P Q G P K G F P G L P G L T G S K G V R G I S G L P G F S G S P G L P G T P G NT G
Top exceptional features (|z-score| rank)
G Patch: +10.51 Frac G: +4.04 gly-gly: -2.48 Frac F: +2.33 pro-gly: -1.89 pol-gly: -1.76 Frac Aliphatic: -1.55 R/K Ratio: -1.45
Show all 90 sequence-feature z-scores
Feature Z-score pol-pol -0.195 pol-hyd +0.000 pol-pos +0.000 pol-neg +0.000 pol-aro +0.000 pol-ala +0.000 pol-pro -0.504 pol-gly -1.758 hyd-hyd +0.000 hyd-pos +0.000 hyd-neg +0.000 hyd-aro +0.000 hyd-ala +0.000 hyd-pro +0.000 hyd-gly +0.000 pos-pos +0.000 pos-neg +0.000 pos-aro +0.000 pos-ala +0.000 pos-pro +0.000 pos-gly +0.000 neg-neg +0.000 neg-aro +0.000 neg-ala +0.000 neg-pro +0.000 neg-gly +0.000 aro-aro +0.000 aro-ala +0.000 aro-pro +0.000 aro-gly +0.000 ala-ala +0.000 ala-pro +0.000 ala-gly +0.000 pro-pro -0.342 pro-gly -1.888 gly-gly -2.477 Frac A -1.166 Frac C -0.582 Frac D -1.234 Frac E -0.728 Frac F +2.335 Frac G +4.043 Frac H -0.849 Frac I -0.200 Frac K +0.397 Frac L +0.308 Frac M -0.832 Frac N -0.544 Frac P +1.154 Frac Q -0.592 Frac R -1.029 Frac S -0.833 Frac T -0.037 Frac V -0.804 Frac W -0.508 Frac Y -0.609 Frac K+R -0.391 Frac D+E -1.147 Frac Polar +1.154 Frac Aliphatic -1.548 Frac Aromatic +0.947 R/K Ratio -1.454 E/D Ratio +1.282 Frac Chain Expanding -0.484 FCR -1.119 NCPR +0.611 Hydrophobicity +0.956 Disorder Promoting +0.564 Iso point +0.872 PPII -0.047 A Patch -0.265 C Patch -0.009 D Patch -0.178 E Patch -0.349 F Patch -0.012 G Patch +10.505 H Patch -0.077 I Patch -0.011 K Patch -0.253 L Patch -0.096 M Patch -0.026 N Patch -0.076 P Patch +0.630 Q Patch -0.160 R Patch -0.247 S Patch -0.481 T Patch -0.147 V Patch -0.051 Y Patch -0.022 RG Frac -0.130
IDR 2
Cluster 22
Residues 151–471 · 320 aa
(19.2% of protein) · Min inter-cluster distance: 76.254
Well-mixed P and G
Sequence
L K G Q K G A P A K EED I E L D A K G D P G L P G A P G P Q G L P G PP G F P G P V G PP G PP G FF G F P G A M G P R G P K G H M G E R VI G H K G E R G V K G L T G PP G PP G T VIV T L T G P D N R T D L K G E K G D K G A M G E P G PP G P S G L P G E S Y G S E K G A P G D P G L Q G K P G K D G V P G F P G S E G V K G N R G F P G LM G ED G I K G Q K G D I G PP G F R G P T E YY D T Y Q E K G DE G T P G PP G P R G A R G P Q G P S G PP G V P G S P G SS R P G L R G A P G W P G L K G S K G E R G R P G K D A M G T P G S P G C A G S P G L P G S P G PP G PP G D IV F RK G PP G D H G L P G Y L G S P G I P G V D G P K G E
Top exceptional features (|z-score| rank)
RG Frac: +8.53 G Patch: +8.32 pro-gly: -4.00 gly-gly: -3.93 Frac G: +3.30 pol-gly: -3.18 pos-gly: -3.17 hyd-gly: -2.91
Show all 90 sequence-feature z-scores
Feature Z-score pol-pol -0.507 pol-hyd -0.766 pol-pos -0.331 pol-neg +0.000 pol-aro +0.000 pol-ala +0.000 pol-pro +0.490 pol-gly -3.180 hyd-hyd -0.942 hyd-pos -0.151 hyd-neg +0.000 hyd-aro +0.000 hyd-ala +0.000 hyd-pro +1.527 hyd-gly -2.911 pos-pos +0.906 pos-neg +0.000 pos-aro +0.000 pos-ala +0.000 pos-pro +2.808 pos-gly -3.174 neg-neg +0.000 neg-aro +0.000 neg-ala +0.000 neg-pro +0.000 neg-gly +0.000 aro-aro +0.000 aro-ala +0.000 aro-pro +0.000 aro-gly +0.000 ala-ala +0.000 ala-pro +0.000 ala-gly +0.000 pro-pro +0.674 pro-gly -3.996 gly-gly -3.929 Frac A -0.790 Frac C -0.369 Frac D -0.031 Frac E -0.602 Frac F +0.607 Frac G +3.302 Frac H -0.506 Frac I +0.203 Frac K +0.138 Frac L -0.338 Frac M -0.028 Frac N -0.789 Frac P +1.277 Frac Q -0.792 Frac R -0.499 Frac S -1.265 Frac T -0.653 Frac V -0.169 Frac W -0.223 Frac Y +0.317 Frac K+R -0.230 Frac D+E -0.476 Frac Polar +0.109 Frac Aliphatic -0.914 Frac Aromatic +0.507 R/K Ratio -0.657 E/D Ratio -0.565 Frac Chain Expanding +0.317 FCR -0.509 NCPR +0.209 Hydrophobicity +0.509 Disorder Promoting +0.527 Iso point +0.401 PPII +0.377 A Patch -0.265 C Patch -0.009 D Patch -0.178 E Patch -0.349 F Patch -0.012 G Patch +8.321 H Patch -0.077 I Patch -0.011 K Patch -0.253 L Patch -0.096 M Patch -0.026 N Patch -0.076 P Patch +1.941 Q Patch -0.160 R Patch -0.247 S Patch -0.481 T Patch -0.147 V Patch -0.051 Y Patch -0.022 RG Frac +8.529
IDR 3
Cluster 22
Residues 491–1445 · 954 aa
(57.1% of protein) · Min inter-cluster distance: 65.689
Well-mixed P and G
Note: this region spans the majority of the protein sequence, which may indicate a structured domain (e.g. a collagen triple helix or repetitive fibrous domain) that AlphaFold2 monomer predictions and sequence-based disorder predictors can misclassify as disordered. Interpret this grammar assignment with caution.
Sequence
P G L H G V K G I P G R Q G AA G L K G S P G S P G NT G L P G F P G F P G A Q G D P G L K G E K G E T L Q P E G Q V G V P G D P G L R G Q P G RK G L D G I P G T P G V K G L P G P K G E L A L S G E K G D Q G PP G D P G S P G S P G P A G P A G PP G Y G P Q G E P G L Q G TQ G V P G A P G PP G E A G P R G E L S V ST P V P G PP G PP G PP G H P G P Q G PP G I P G S L G K C G D P G L P G P D G E P G I P G I G F P G PP G P K G D Q G F P G T K G S L G C P G K M G E P G L P G K P G L P G A K G E P A V A M P GG P G T P G F P G E R G NS G E H G E I G L P G L P G L P G T P G N E G L D G P R G D P G Q P G PP G E Q G PP G R C I E G P R G A Q G L P G L N G L K G QQ G RR G K T G P K G D P G I P G L D R S G F P G E T G S P G I P G HQ G E M G P L G Q R G Y P G N P G IL G PP G ED G VI G MM G F P G A I G PP G PP G N P G T P G Q R G S P G I P G V K G Q R G T P G A K G E Q G D K G N P G P S E I SH VI G D K G E P G L K G F A G N P G E K G N R G V P G M P G L K G L K G L P G P A G PP G P R G D L G ST G N P G E P G L R G I P G S M G N M G M P G S K G KR G T L G F P G R A G R P G L P G I H G L Q G D K G E P G Y S E G T R P G PP G P T G D P G L P G D M G KK G E M G Q P G PP G H L G P A G P E G A P G S P G S P G L P G K P G P H G D L G F K G I K G LL G PP G I R G PP G L P G F P G S P G P M G I R G D Q G R D G I P G P A G E K G E T G LL R A PP G P R G N P G A Q G A K G D R G A P G F P G L P G RK G A M G D A G P R G P T G I E G F P G PP G L P G A II P G QT G N R G PP G S R G S P G A P G PP G PP G SH VI G I K G D K G S M G H P G P K G PP G T A G D M G PP G R L G A P G T P G L P G P R G D P G F Q G F P G V K G E K G N P G F L G S I G PP G P I G P K G PP G V R G D P G T L K II S L P G S P G PP G T P G E P G M Q G E P G PP G PP G N L G P C G P R G K P G K D G K P G T P G P A G E K G N K G S K G E P G P A G S D G L P G L K G KR G D S G S P A T W TT R G
Top exceptional features (|z-score| rank)
RG Frac: +10.19 G Patch: +9.86 gly-gly: -8.68 pro-gly: -6.78 pol-gly: -6.27 hyd-gly: -6.12 Frac G: +3.79 P Patch: +2.01
Show all 90 sequence-feature z-scores
Feature Z-score pol-pol -1.035 pol-hyd -0.565 pol-pos +0.000 pol-neg +0.000 pol-aro +0.000 pol-ala +0.000 pol-pro +0.194 pol-gly -6.273 hyd-hyd -0.010 hyd-pos +0.000 hyd-neg +0.000 hyd-aro +0.000 hyd-ala +0.000 hyd-pro +0.575 hyd-gly -6.115 pos-pos +0.000 pos-neg +0.000 pos-aro +0.000 pos-ala +0.000 pos-pro +0.000 pos-gly +0.000 neg-neg +0.000 neg-aro +0.000 neg-ala +0.000 neg-pro +0.000 neg-gly +0.000 aro-aro +0.000 aro-ala +0.000 aro-pro +0.000 aro-gly +0.000 ala-ala +0.000 ala-pro +0.000 ala-gly +0.000 pro-pro -0.632 pro-gly -6.783 gly-gly -8.682 Frac A -0.786 Frac C -0.296 Frac D -0.452 Frac E -0.771 Frac F +0.141 Frac G +3.789 Frac H -0.466 Frac I +0.685 Frac K -0.134 Frac L -0.029 Frac M +0.031 Frac N -0.451 Frac P +1.488 Frac Q -0.557 Frac R -0.535 Frac S -1.355 Frac T -0.649 Frac V -0.737 Frac W -0.412 Frac Y -0.423 Frac K+R -0.457 Frac D+E -0.807 Frac Polar +0.577 Frac Aliphatic -0.813 Frac Aromatic -0.342 R/K Ratio -0.464 E/D Ratio -0.336 Frac Chain Expanding +0.004 FCR -0.906 NCPR +0.310 Hydrophobicity +0.682 Disorder Promoting +0.621 Iso point +0.670 PPII +0.437 A Patch -0.265 C Patch -0.009 D Patch -0.178 E Patch -0.349 F Patch -0.012 G Patch +9.861 H Patch -0.077 I Patch -0.011 K Patch -0.253 L Patch -0.096 M Patch -0.026 N Patch -0.076 P Patch +2.014 Q Patch -0.160 R Patch -0.247 S Patch -0.481 T Patch -0.147 V Patch -0.051 Y Patch -0.022 RG Frac +10.194