NephVar / Molecular Grammars / LMX1B

LMX1B LMX1B

SRNS panel · 402 aa · UniProt O60663 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 12
Residues 172–242 · 70 aa (17.4% of protein) · Min inter-cluster distance: 2.563
Blocks of positive, negative & polar residues
Sequence
KDLLSSVSPDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSS
Top exceptional features (|z-score| rank)
pos-neg: +2.96pol-neg: +2.64neg-neg: +2.11R Patch: +2.09hyd-neg: +2.06pol-pos: +2.06Frac D: +1.86hyd-pos: +1.84
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.795
pol-hyd-0.335
pol-pos+2.058
pol-neg+2.636
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.944
hyd-pos+1.840
hyd-neg+2.060
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.609
pos-neg+2.959
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+2.114
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.634
Frac C-0.582
Frac D+1.861
Frac E-0.495
Frac F+0.809
Frac G+0.039
Frac H-0.849
Frac I-0.180
Frac K+0.947
Frac L-0.453
Frac M-0.097
Frac N-0.989
Frac P-0.591
Frac Q+0.058
Frac R+0.395
Frac S+0.695
Frac T-0.322
Frac V+0.255
Frac W-0.508
Frac Y-0.609
Frac K+R+0.969
Frac D+E+0.510
Frac Polar-0.251
Frac Aliphatic-0.797
Frac Aromatic-0.058
R/K Ratio-0.398
E/D Ratio-1.488
Frac Chain Expanding+0.768
FCR+1.018
NCPR+0.252
Hydrophobicity-0.694
Disorder Promoting+0.992
Iso point+0.536
PPII-0.397
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch+2.093
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 10
Residues 304–355 · 51 aa (12.7% of protein) · Min inter-cluster distance: 10.05
Well-mixed hydrophobics, enriched in M
Sequence
MMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTPPQMPGDHMNPYGNDSI
Top exceptional features (|z-score| rank)
Frac M: +4.21Frac Y: +2.88Disorder Promoting: -2.08Frac Q: +1.83Frac Aromatic: +1.80Frac K+R: -1.68FCR: -1.64E/D Ratio: -1.49
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.364
pol-hyd-0.666
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-1.135
pol-gly+0.000
hyd-hyd-0.136
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.267
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.707
pro-gly+0.000
gly-gly+0.000
Frac A-0.341
Frac C-0.582
Frac D+0.182
Frac E-1.059
Frac F+0.302
Frac G-0.079
Frac H-0.132
Frac I+1.077
Frac K-1.083
Frac L-0.558
Frac M+4.212
Frac N+0.269
Frac P+0.899
Frac Q+1.833
Frac R-1.304
Frac S-0.404
Frac T-0.404
Frac V-0.595
Frac W-0.508
Frac Y+2.875
Frac K+R-1.677
Frac D+E-0.724
Frac Polar+0.286
Frac Aliphatic+0.798
Frac Aromatic+1.800
R/K Ratio-0.133
E/D Ratio-1.488
Frac Chain Expanding-1.277
FCR-1.643
NCPR-0.556
Hydrophobicity+0.861
Disorder Promoting-2.077
Iso point-1.213
PPII+0.804
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130