NephVar / Molecular Grammars / NPHP4

NPHP4 NPHP4

NPHP panel · 1426 aa · UniProt O75161 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 27
Residues 446–547 · 101 aa (7.1% of protein) · Min inter-cluster distance: 10.331
P patches
Sequence
FSLGSEEHLDAPTEPVSGPKVERRPSRKPPTSPSSPPAPVPRVLAAPQNSPVGPGLSISQLAASPRSPTQHCLARPTSQLPHGSQASPAQAQEFPLEAGIS
Top exceptional features (|z-score| rank)
pro-pro: -1.48Frac P: +1.21ala-ala: +1.17Hydrophobicity: +1.11E/D Ratio: +1.10PPII: +1.06FCR: -1.04Frac D: -1.00
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.880
pol-hyd+0.605
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.381
pol-pro-0.798
pol-gly+0.000
hyd-hyd-0.769
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala-0.470
hyd-pro-0.381
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+1.172
ala-pro-0.447
ala-gly+0.000
pro-pro-1.484
pro-gly+0.000
gly-gly+0.000
Frac A+0.578
Frac C+0.093
Frac D-0.996
Frac E-0.461
Frac F+0.313
Frac G-0.387
Frac H+0.237
Frac I+0.098
Frac K-0.731
Frac L+0.588
Frac M-0.832
Frac N-0.672
Frac P+1.205
Frac Q+0.328
Frac R-0.126
Frac S+0.500
Frac T-0.395
Frac V+0.498
Frac W-0.508
Frac Y-0.609
Frac K+R-0.629
Frac D+E-0.829
Frac Polar-0.063
Frac Aliphatic+0.839
Frac Aromatic-0.385
R/K Ratio+0.760
E/D Ratio+1.104
Frac Chain Expanding-0.351
FCR-1.036
NCPR+0.213
Hydrophobicity+1.115
Disorder Promoting+0.179
Iso point+0.401
PPII+1.057
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.978
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 6
Residues 834–871 · 37 aa (2.6% of protein) · Min inter-cluster distance: 2.161
S patches
Sequence
KVRGCSTLPPSRSRVISNDGASRFSGGSLLTTGSSRR
Top exceptional features (|z-score| rank)
Frac R: +1.91Frac S: +1.77PPII: -1.74Iso point: +1.65NCPR: +1.54E/D Ratio: -1.49Frac E: -1.35pol-pol: -1.35
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.352
pol-hyd-0.584
pol-pos+0.279
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly-1.203
hyd-hyd+0.654
hyd-pos-0.107
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.119
pos-pos+1.339
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly-0.384
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly-0.541
Frac A-0.924
Frac C+1.261
Frac D-0.584
Frac E-1.354
Frac F+0.721
Frac G+0.838
Frac H-0.849
Frac I+0.462
Frac K-0.603
Frac L+0.642
Frac M-0.832
Frac N-0.122
Frac P-0.837
Frac Q-1.207
Frac R+1.911
Frac S+1.772
Frac T+0.535
Frac V+0.664
Frac W-0.508
Frac Y-0.609
Frac K+R+0.826
Frac D+E-1.316
Frac Polar+1.287
Frac Aliphatic-0.274
Frac Aromatic-0.116
R/K Ratio+1.188
E/D Ratio-1.488
Frac Chain Expanding-1.122
FCR-0.450
NCPR+1.539
Hydrophobicity+1.142
Disorder Promoting-0.811
Iso point+1.646
PPII-1.737
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 29
Residues 893–940 · 47 aa (3.3% of protein) · Min inter-cluster distance: 3.629
High R fraction
Sequence
HARQGKGPQDVSRESDATRRRKLERMRSVRLQEAGGDLGRRGTSVLA
Top exceptional features (|z-score| rank)
Frac R: +2.92gly-gly: +1.80Frac K+R: +1.70G Patch: +1.62pos-gly: +1.58Iso point: +1.51Frac P: -1.30NCPR: +1.24
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.349
pol-hyd-0.692
pol-pos+0.020
pol-neg-0.824
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.164
hyd-hyd+0.294
hyd-pos-0.167
hyd-neg-0.349
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.756
pos-pos+0.269
pos-neg+0.604
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+1.585
neg-neg-0.521
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.433
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+1.801
Frac A+0.141
Frac C-0.582
Frac D+0.302
Frac E-0.395
Frac F-0.807
Frac G+0.717
Frac H-0.071
Frac I-0.900
Frac K-0.327
Frac L+0.757
Frac M+0.263
Frac N-0.989
Frac P-1.302
Frac Q+0.206
Frac R+2.915
Frac S-0.598
Frac T-0.329
Frac V+1.021
Frac W-0.508
Frac Y-0.609
Frac K+R+1.701
Frac D+E-0.158
Frac Polar-0.416
Frac Aliphatic+0.805
Frac Aromatic-1.123
R/K Ratio+1.237
E/D Ratio-0.565
Frac Chain Expanding+0.233
FCR+0.995
NCPR+1.238
Hydrophobicity-0.374
Disorder Promoting+0.501
Iso point+1.511
PPII-1.229
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+1.625
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130