NephVar / Molecular Grammars / GLIS2

GLIS2 GLIS2

NPHP panel · 524 aa · UniProt Q9BZE0 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 14
Residues 20–63 · 43 aa (8.2% of protein) · Min inter-cluster distance: 8.225
Blocks of positive & P residues
Sequence
REKRERTLGVVRPRALHRELGLVDDSPTPGSPGSPPSGFLLNS
Top exceptional features (|z-score| rank)
hyd-pro: +2.71Frac L: +2.32pos-pro: +2.16P Patch: +2.13neg-pro: +1.86pos-pos: +1.84pol-pro: -1.60pro-pro: +1.52
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.117
pol-hyd+0.915
pol-pos+1.008
pol-neg-0.071
pol-aro+0.000
pol-ala+0.000
pol-pro-1.603
pol-gly-1.473
hyd-hyd+1.295
hyd-pos+0.809
hyd-neg+0.262
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+2.711
hyd-gly-0.749
pos-pos+1.842
pos-neg-0.368
pos-aro+0.000
pos-ala+0.000
pos-pro+2.161
pos-gly+1.435
neg-neg+1.146
neg-aro+0.000
neg-ala+0.000
neg-pro+1.862
neg-gly+0.626
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.522
pro-gly-1.192
gly-gly-1.211
Frac A-0.994
Frac C-0.582
Frac D-0.115
Frac E-0.305
Frac F+0.508
Frac G+0.533
Frac H+0.002
Frac I-0.900
Frac K-0.670
Frac L+2.316
Frac M-0.832
Frac N-0.243
Frac P+0.375
Frac Q-1.207
Frac R+1.463
Frac S-0.131
Frac T-0.240
Frac V+1.238
Frac W-0.508
Frac Y-0.609
Frac K+R+0.477
Frac D+E-0.289
Frac Polar-0.562
Frac Aliphatic+0.433
Frac Aromatic-0.256
R/K Ratio+1.188
E/D Ratio-0.182
Frac Chain Expanding+0.378
FCR+0.095
NCPR+0.532
Hydrophobicity+0.750
Disorder Promoting-1.037
Iso point+1.343
PPII-0.280
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+2.128
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 6
Residues 80–117 · 37 aa (7.1% of protein) · Min inter-cluster distance: 4.584
S patches
Sequence
LSLSPPSGLDSPNGSSSLSPERQGNGDLPPVPSASDF
Top exceptional features (|z-score| rank)
Frac L: +2.19Frac S: +2.18E/D Ratio: -1.49hyd-pro: -1.45neg-neg: -1.33Frac K+R: -1.32Frac T: -1.28Iso point: -1.21
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.159
pol-hyd-0.039
pol-pos+0.000
pol-neg+0.268
pol-aro+0.000
pol-ala+0.000
pol-pro+0.231
pol-gly-0.802
hyd-hyd-0.681
hyd-pos+0.000
hyd-neg-0.933
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.448
hyd-gly-0.114
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-1.332
neg-aro+0.000
neg-ala+0.000
neg-pro+0.258
neg-gly-1.044
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.412
pro-gly+0.806
gly-gly-0.105
Frac A-0.924
Frac C-0.582
Frac D+0.717
Frac E-0.948
Frac F+0.721
Frac G+0.401
Frac H-0.849
Frac I-0.900
Frac K-1.083
Frac L+2.190
Frac M-0.832
Frac N+0.745
Frac P+1.079
Frac Q-0.609
Frac R-0.768
Frac S+2.177
Frac T-1.284
Frac V-0.324
Frac W-0.508
Frac Y-0.609
Frac K+R-1.319
Frac D+E-0.383
Frac Polar+0.755
Frac Aliphatic-0.274
Frac Aromatic-0.116
R/K Ratio+0.598
E/D Ratio-1.488
Frac Chain Expanding-0.575
FCR-1.152
NCPR-0.579
Hydrophobicity+1.083
Disorder Promoting-0.811
Iso point-1.213
PPII-0.081
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.046
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 16
Residues 438–487 · 49 aa (9.4% of protein) · Min inter-cluster distance: 0.428
Blocks of polar residues
Sequence
GGKAEGEKGRGSVPTRALGMEGHKTPLERTESSCSRPSPDGLPLLPGTV
Top exceptional features (|z-score| rank)
pol-hyd: +2.28pol-gly: +2.00pos-pos: -1.68Frac G: +1.62pos-neg: -1.29neg-gly: -1.27Frac L: +1.24pos-gly: -1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.754
pol-hyd+2.278
pol-pos-0.344
pol-neg+0.682
pol-aro+0.000
pol-ala+0.000
pol-pro+0.723
pol-gly+2.003
hyd-hyd+0.663
hyd-pos+0.673
hyd-neg+0.630
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.076
hyd-gly-0.623
pos-pos-1.683
pos-neg-1.292
pos-aro+0.000
pos-ala+0.000
pos-pro-0.151
pos-gly-1.225
neg-neg-0.377
neg-aro+0.000
neg-ala+0.000
neg-pro+0.522
neg-gly-1.273
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.210
pro-gly+0.154
gly-gly+0.551
Frac A-0.671
Frac C+0.810
Frac D-0.743
Frac E+0.180
Frac F-0.807
Frac G+1.623
Frac H-0.103
Frac I-0.900
Frac K+0.004
Frac L+1.242
Frac M+0.218
Frac N-0.989
Frac P+0.133
Frac Q-1.207
Frac R+0.314
Frac S-0.344
Frac T+0.548
Frac V+0.180
Frac W-0.508
Frac Y-0.609
Frac K+R+0.213
Frac D+E-0.218
Frac Polar+0.251
Frac Aliphatic-0.031
Frac Aromatic-1.123
R/K Ratio+0.102
E/D Ratio+0.898
Frac Chain Expanding+0.066
FCR-0.024
NCPR+0.305
Hydrophobicity+0.664
Disorder Promoting+0.259
Iso point+0.401
PPII-0.439
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.133
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130