NephVar / Molecular Grammars / FREM2

FREM2 FREM2

CAKUT panel · 3169 aa · UniProt Q5SZK8 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 28
Residues 655–685 · 30 aa (0.9% of protein) · Min inter-cluster distance: 10.432
High aromatic fraction, specifically Ys
Sequence
RHSGPHSPGPVTDQFTFRVQDNHDPPNQSG
Top exceptional features (|z-score| rank)
Frac F: +2.96Frac H: +2.81E/D Ratio: -2.41Frac Aliphatic: -2.27Frac L: -1.68Frac Polar: +1.48Frac A: -1.42Frac Aromatic: +1.36
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.009
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-1.011
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.787
pro-gly+0.000
gly-gly+0.000
Frac A-1.420
Frac C-0.582
Frac D+1.173
Frac E-1.354
Frac F+2.963
Frac G+0.270
Frac H+2.810
Frac I-0.900
Frac K-1.083
Frac L-1.681
Frac M-0.832
Frac N+1.149
Frac P+0.760
Frac Q+1.007
Frac R+0.018
Frac S-0.375
Frac T+0.212
Frac V+1.125
Frac W-0.508
Frac Y-0.609
Frac K+R-0.795
Frac D+E-0.476
Frac Polar+1.482
Frac Aliphatic-2.273
Frac Aromatic+1.361
R/K Ratio+1.025
E/D Ratio-2.411
Frac Chain Expanding-0.484
FCR-0.879
NCPR-0.163
Hydrophobicity-0.945
Disorder Promoting-0.034
Iso point-0.204
PPII+0.087
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 25
Residues 3032–3063 · 31 aa (1.0% of protein) · Min inter-cluster distance: 13.573
Blocks of positive residues
Sequence
EYHSLVSQGKPQSTTKSRKKREIRSTPSLAW
Top exceptional features (|z-score| rank)
hyd-pos: +2.66Frac W: +2.43NCPR: +1.53pol-pos: +1.39Frac K+R: +1.31Frac Y: +1.30Frac Aromatic: +1.28Frac D: -1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.433
pol-hyd+0.599
pol-pos+1.391
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.340
hyd-pos+2.660
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.666
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.829
Frac C-0.582
Frac D-1.234
Frac E-0.384
Frac F-0.807
Frac G-0.826
Frac H+0.331
Frac I+0.726
Frac K+1.209
Frac L+0.167
Frac M-0.832
Frac N-0.989
Frac P-0.689
Frac Q+0.222
Frac R+0.615
Frac S+1.027
Frac T+0.887
Frac V-0.132
Frac W+2.427
Frac Y+1.302
Frac K+R+1.310
Frac D+E-0.885
Frac Polar+0.361
Frac Aliphatic-0.729
Frac Aromatic+1.281
R/K Ratio-0.369
E/D Ratio+0.898
Frac Chain Expanding-0.267
FCR+0.192
NCPR+1.531
Hydrophobicity-0.505
Disorder Promoting+0.082
Iso point+1.208
PPII-0.266
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 16
Residues 3139–3169 · 30 aa (0.9% of protein) · Min inter-cluster distance: 2.04
Blocks of polar residues
Sequence
SFRGKDAPKGSSSSEPMVPPQSHHNDSSEV
Top exceptional features (|z-score| rank)
pol-pol: +3.63pol-pro: +2.54Frac S: +2.12Frac L: -1.68Frac H: +1.59Frac T: -1.28Frac Aliphatic: -1.19Frac V: +1.12
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+3.626
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.727
pol-aro+0.000
pol-ala+0.000
pol-pro+2.540
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.556
neg-aro+0.000
neg-ala+0.000
neg-pro+0.793
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.552
pro-gly+0.000
gly-gly+0.000
Frac A-0.809
Frac C-0.582
Frac D+0.370
Frac E-0.352
Frac F+1.078
Frac G-0.269
Frac H+1.590
Frac I-0.900
Frac K+0.101
Frac L-1.681
Frac M+0.883
Frac N+0.080
Frac P+0.287
Frac Q-0.469
Frac R-0.643
Frac S+2.123
Frac T-1.284
Frac V+1.125
Frac W-0.508
Frac Y-0.609
Frac K+R-0.354
Frac D+E-0.092
Frac Polar+0.826
Frac Aliphatic-1.185
Frac Aromatic+0.119
R/K Ratio-0.561
E/D Ratio-0.565
Frac Chain Expanding-0.147
FCR-0.301
NCPR-0.163
Hydrophobicity-0.419
Disorder Promoting+0.564
Iso point-0.271
PPII-0.093
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.025
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130