NephVar / Molecular Grammars / SALL1

SALL1 SALL1

CAKUT panel · 1324 aa · UniProt Q9NSC2 · 7 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 9
Residues 0–43 · 43 aa (3.2% of protein) · Min inter-cluster distance: 2.222
Blocks of positive & negative residues
MSRRKQAKPQHFQSDPEVASLPRRDGDTEKGQPSRPTKSKDAH
Disorder Promoting: +1.89Hydrophobicity: -1.67Frac K+R: +1.40E/D Ratio: -1.25pro-pro: -1.20pol-pro: -1.18neg-neg: +1.08Frac Aliphatic: -1.08
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.632
pol-hyd+0.000
pol-pos-0.332
pol-neg+0.018
pol-aro+0.000
pol-ala+0.000
pol-pro-1.177
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.482
pos-neg+1.064
pos-aro+0.000
pos-ala+0.000
pos-pro-0.141
pos-gly+0.000
neg-neg+1.085
neg-aro+0.000
neg-ala+0.000
neg-pro+0.594
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-1.198
pro-gly+0.000
gly-gly+0.000
Frac A-0.140
Frac C-0.582
Frac D+1.005
Frac E-0.655
Frac F+0.508
Frac G-0.595
Frac H+0.852
Frac I-0.900
Frac K+0.982
Frac L-1.015
Frac M+0.365
Frac N-0.989
Frac P+0.045
Frac Q+0.853
Frac R+1.002
Frac S-0.131
Frac T-0.240
Frac V-0.461
Frac W-0.508
Frac Y-0.609
Frac K+R+1.400
Frac D+E-0.021
Frac Polar-0.333
Frac Aliphatic-1.084
Frac Aromatic-0.256
R/K Ratio-0.133
E/D Ratio-1.245
Frac Chain Expanding+1.084
FCR+0.901
NCPR+0.937
Hydrophobicity-1.665
Disorder Promoting+1.887
Iso point+0.939
PPII+0.595
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 3
Residues 75–178 · 103 aa (7.8% of protein) · Min inter-cluster distance: 7.287
Small negative blocks
ENPASPPETFSPSPPPDNPDEQMNDTVNKTDQVDCSDLSEHNGLDREESMEVEAPVANKSGSGTSSGSHSSTAPSSSSSSSSSSGGGGSSSTGTSAITTSLPQ
pol-neg: +2.79Frac S: +2.20neg-neg: +1.99pol-pro: +1.97pol-pol: +1.96S Patch: +1.93Frac Polar: +1.77pro-pro: +1.46
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.959
pol-hyd+0.000
pol-pos+0.000
pol-neg+2.792
pol-aro+0.000
pol-ala+0.000
pol-pro+1.968
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+1.986
neg-aro+0.000
neg-ala+0.000
neg-pro+1.264
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.461
pro-gly+0.000
gly-gly+0.000
Frac A-0.530
Frac C+0.080
Frac D+0.402
Frac E-0.187
Frac F-0.258
Frac G+0.066
Frac H-0.139
Frac I-0.411
Frac K-0.738
Frac L-0.847
Frac M+0.167
Frac N+0.879
Frac P-0.089
Frac Q-0.562
Frac R-1.112
Frac S+2.200
Frac T+0.677
Frac V+0.108
Frac W-0.508
Frac Y-0.609
Frac K+R-1.292
Frac D+E+0.049
Frac Polar+1.775
Frac Aliphatic-0.985
Frac Aromatic-0.761
R/K Ratio-0.561
E/D Ratio-0.408
Frac Chain Expanding-1.008
FCR-0.809
NCPR-0.887
Hydrophobicity+0.220
Disorder Promoting+0.419
Iso point-1.145
PPII-0.736
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+0.634
F Patch-0.012
G Patch+0.171
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.413
Q Patch-0.160
R Patch-0.247
S Patch+1.932
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 6
Residues 340–376 · 36 aa (2.7% of protein) · Min inter-cluster distance: 3.13
S patches
MNILAAAVTTPSSEKVASSAGASHVSNPAVSSSSSP
Frac Aliphatic: +2.98Hydrophobicity: +2.79Frac V: +2.75Frac S: +2.71Frac Chain Expanding: -2.45Frac A: +2.15FCR: -1.84pol-ala: +1.31
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.630
pol-hyd+0.079
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+1.310
pol-pro+0.000
pol-gly+0.000
hyd-hyd-0.666
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala-1.049
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.175
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+2.147
Frac C-0.582
Frac D-1.234
Frac E-0.936
Frac F-0.807
Frac G-0.898
Frac H+0.167
Frac I+0.500
Frac K-0.590
Frac L-0.885
Frac M+0.597
Frac N+0.793
Frac P-0.422
Frac Q-1.207
Frac R-1.304
Frac S+2.705
Frac T-0.037
Frac V+2.749
Frac W-0.508
Frac Y-0.609
Frac K+R-1.309
Frac D+E-1.307
Frac Polar+0.881
Frac Aliphatic+2.984
Frac Aromatic-1.123
R/K Ratio-0.864
E/D Ratio+0.358
Frac Chain Expanding-2.451
FCR-1.841
NCPR+0.127
Hydrophobicity+2.788
Disorder Promoting-0.933
Iso point+0.401
PPII-0.742
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.088
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 4 Cluster 6
Residues 573–653 · 80 aa (6.0% of protein) · Min inter-cluster distance: 0.787
S patches
EPAPIPISHSATSPPGSVKSDSGGPESATRNLGGLPEEAEGSTLPPSGGKSEESGMVTNSVPTASSSVLSSPAADCGPAG
pol-neg: +1.72hyd-neg: +1.49Hydrophobicity: +1.43Frac S: +1.31Frac Q: -1.21pol-gly: +1.20Frac K+R: -1.18Frac Aromatic: -1.12
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.368
pol-hyd-0.791
pol-pos+0.000
pol-neg+1.723
pol-aro+0.000
pol-ala+0.000
pol-pro+0.650
pol-gly+1.202
hyd-hyd+0.517
hyd-pos+0.000
hyd-neg+1.486
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.585
hyd-gly+0.347
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.931
neg-aro+0.000
neg-ala+0.000
neg-pro+0.610
neg-gly-0.880
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.342
pro-gly-0.398
gly-gly+0.946
Frac A+0.414
Frac C+0.270
Frac D-0.633
Frac E-0.039
Frac F-0.807
Frac G+0.876
Frac H-0.392
Frac I+0.360
Frac K-0.639
Frac L-0.249
Frac M-0.189
Frac N-0.187
Frac P+0.524
Frac Q-1.207
Frac R-1.057
Frac S+1.311
Frac T+0.118
Frac V+0.516
Frac W-0.508
Frac Y-0.609
Frac K+R-1.181
Frac D+E-0.332
Frac Polar+0.785
Frac Aliphatic+0.514
Frac Aromatic-1.123
R/K Ratio-0.561
E/D Ratio+0.742
Frac Chain Expanding-0.821
FCR-1.023
NCPR-0.526
Hydrophobicity+1.430
Disorder Promoting+0.415
Iso point-1.078
PPII-0.155
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+0.507
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 5 Cluster 4
Residues 789–860 · 71 aa (5.4% of protein) · Min inter-cluster distance: 2.207
Weak negative charge, high N fraction
GGQIPNTPVPDSYSESMESDTGSFDEKNFDDLDNFSDENMEDCPEGSIPDTPKSADASQDSLSSSPLPLEM
Frac D: +2.50S Patch: +2.06hyd-pro: -1.99NCPR: -1.83pol-pol: -1.66Frac F: +1.58hyd-hyd: -1.48Iso point: -1.35
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.662
pol-hyd-1.211
pol-pos+0.000
pol-neg-0.952
pol-aro+0.000
pol-ala+0.000
pol-pro-0.449
pol-gly+0.000
hyd-hyd-1.477
hyd-pos+0.000
hyd-neg-0.919
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.990
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.659
neg-aro+0.000
neg-ala+0.000
neg-pro+0.705
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.167
pro-gly+0.000
gly-gly+0.000
Frac A-0.904
Frac C+0.378
Frac D+2.495
Frac E+0.128
Frac F+1.583
Frac G-0.436
Frac H-0.849
Frac I+0.520
Frac K-0.583
Frac L-0.067
Frac M+1.342
Frac N+0.818
Frac P-0.006
Frac Q-0.583
Frac R-1.304
Frac S+0.870
Frac T-0.336
Frac V-0.796
Frac W-0.508
Frac Y+0.225
Frac K+R-1.304
Frac D+E+1.291
Frac Polar-0.024
Frac Aliphatic-0.603
Frac Aromatic+0.976
R/K Ratio-1.292
E/D Ratio-1.105
Frac Chain Expanding+0.133
FCR+0.118
NCPR-1.835
Hydrophobicity+0.183
Disorder Promoting-1.249
Iso point-1.347
PPII-0.483
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+2.065
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 6 Cluster 24
Residues 884–964 · 80 aa (6.0% of protein) · Min inter-cluster distance: 1.464
Weak negative charge
LKSVENGSIEGDVLTNDSSSVGGDMESQSAGSPAISESTSSMQALSPSNSTQEFHKSPSIEEKPQRAVPSEFANGLSPTP
hyd-neg: -1.84Frac S: +1.69hyd-hyd: -1.52Iso point: -1.08Frac Chain Expanding: -1.07Frac R: -1.06Frac K+R: -1.01Frac I: +0.99
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.171
pol-hyd+0.295
pol-pos+0.000
pol-neg-0.349
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-1.517
hyd-pos+0.000
hyd-neg-1.844
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg-0.739
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.274
Frac C-0.582
Frac D-0.332
Frac E+0.149
Frac F+0.607
Frac G-0.135
Frac H-0.392
Frac I+0.990
Frac K-0.417
Frac L-0.249
Frac M+0.455
Frac N+0.615
Frac P-0.363
Frac Q-0.100
Frac R-1.057
Frac S+1.686
Frac T-0.162
Frac V+0.516
Frac W-0.508
Frac Y-0.609
Frac K+R-1.015
Frac D+E-0.044
Frac Polar+0.908
Frac Aliphatic+0.310
Frac Aromatic-0.191
R/K Ratio-0.864
E/D Ratio+0.515
Frac Chain Expanding-1.074
FCR-0.698
NCPR-0.635
Hydrophobicity+0.918
Disorder Promoting-0.708
Iso point-1.078
PPII-0.625
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+0.366
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 7 Cluster 6
Residues 1092–1127 · 35 aa (2.6% of protein) · Min inter-cluster distance: 0.366
S patches
VHVSPQDSKDTPTSHVPSGPLSSSATSPVLLPALP
Frac V: +2.87Hydrophobicity: +2.05E/D Ratio: -2.03pro-pro: -1.73Frac L: +1.59FCR: -1.58Frac S: +1.55hyd-pro: -1.54
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.693
pol-hyd+1.528
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-0.397
pol-gly+0.000
hyd-hyd+1.017
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.540
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-1.733
pro-gly+0.000
gly-gly+0.000
Frac A-0.372
Frac C-0.582
Frac D+0.141
Frac E-1.354
Frac F-0.807
Frac G-0.885
Frac H+1.241
Frac I-0.900
Frac K-0.576
Frac L+1.593
Frac M-0.832
Frac N-0.989
Frac P+1.233
Frac Q-0.575
Frac R-1.304
Frac S+1.552
Frac T+0.639
Frac V+2.865
Frac W-0.508
Frac Y-0.609
Frac K+R-1.299
Frac D+E-0.969
Frac Polar+0.451
Frac Aliphatic+1.301
Frac Aromatic-1.123
R/K Ratio-0.864
E/D Ratio-2.028
Frac Chain Expanding-0.966
FCR-1.580
NCPR-0.122
Hydrophobicity+2.054
Disorder Promoting-0.548
Iso point-0.271
PPII+0.711
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+1.456
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130