NephVar / Molecular Grammars / INVS

INVS INVS

NPHP panel · 1065 aa · UniProt Q9Y283 · 2 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 17
Residues 579–834 · 255 aa (23.9% of protein) · Min inter-cluster distance: 5.056
Weak positive charge
Sequence
NLLMKHEQLRKDAAAKKREEENKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRGSPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVPSVEKSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRHDTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGSARGEAVHAGQNPPHHRTPRNK
Top exceptional features (|z-score| rank)
pol-pro: -2.52pos-neg: -1.68pol-pol: -1.32Frac C: +1.29pol-pos: -1.09Frac R: +1.03neg-pro: +0.98Frac K+R: +0.92
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.317
pol-hyd+0.000
pol-pos-1.092
pol-neg-0.900
pol-aro+0.000
pol-ala+0.000
pol-pro-2.525
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.593
pos-neg-1.682
pos-aro+0.000
pos-ala+0.000
pos-pro-0.162
pos-gly+0.000
neg-neg+0.383
neg-aro+0.000
neg-ala+0.000
neg-pro+0.976
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.375
pro-gly+0.000
gly-gly+0.000
Frac A+0.235
Frac C+1.290
Frac D-0.196
Frac E-0.234
Frac F-0.364
Frac G+0.238
Frac H+0.729
Frac I-0.703
Frac K+0.310
Frac L-0.558
Frac M-0.630
Frac N+0.017
Frac P-0.102
Frac Q+0.182
Frac R+1.029
Frac S-0.287
Frac T-0.668
Frac V-0.021
Frac W-0.151
Frac Y-0.609
Frac K+R+0.917
Frac D+E-0.273
Frac Polar+0.132
Frac Aliphatic-0.546
Frac Aromatic-0.684
R/K Ratio+0.277
E/D Ratio+0.116
Frac Chain Expanding+0.389
FCR+0.395
NCPR+0.810
Hydrophobicity-0.803
Disorder Promoting+0.811
Iso point+0.872
PPII+0.005
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+0.132
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 24
Residues 840–886 · 46 aa (4.3% of protein) · Min inter-cluster distance: 7.11
Weak negative charge
Sequence
TGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSG
Top exceptional features (|z-score| rank)
hyd-hyd: -2.46Frac L: +2.06pol-hyd: -1.64neg-gly: +1.50Frac T: +1.16hyd-gly: -1.07Frac N: -0.99pol-gly: +0.95
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.075
pol-hyd-1.636
pol-pos+0.000
pol-neg-0.767
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.953
hyd-hyd-2.459
hyd-pos+0.000
hyd-neg-0.534
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly-1.075
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.798
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+1.500
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.530
Frac A-0.623
Frac C-0.582
Frac D-0.188
Frac E+0.280
Frac F+0.422
Frac G+0.410
Frac H-0.054
Frac I-0.900
Frac K-0.697
Frac L+2.056
Frac M-0.832
Frac N-0.989
Frac P-0.370
Frac Q-0.244
Frac R-0.011
Frac S+0.407
Frac T+1.155
Frac V-0.517
Frac W-0.508
Frac Y+0.679
Frac K+R-0.527
Frac D+E+0.124
Frac Polar+0.513
Frac Aliphatic-0.169
Frac Aromatic+0.497
R/K Ratio+0.598
E/D Ratio+0.358
Frac Chain Expanding-0.557
FCR-0.251
NCPR-0.441
Hydrophobicity+0.600
Disorder Promoting+0.044
Iso point-0.944
PPII-0.911
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130