NephVar / Molecular Grammars / ROBO2

ROBO2 ROBO2

CAKUT panel · 1378 aa · UniProt Q9HCK4 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 25
Residues 1030–1108 · 78 aa (5.7% of protein) · Min inter-cluster distance: 1.077
Blocks of positive residues
Sequence
MGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPL
Top exceptional features (|z-score| rank)
pos-pro: +5.19pro-gly: +4.05hyd-pos: +3.68Frac N: +2.71R/K Ratio: -2.56pol-pro: +2.21Disorder Promoting: -2.20hyd-pro: -2.04
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.309
pol-hyd+1.431
pol-pos+0.151
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+2.209
pol-gly+0.699
hyd-hyd-0.270
hyd-pos+3.684
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-2.044
hyd-gly+1.567
pos-pos+1.194
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+5.193
pos-gly+0.937
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+1.854
pro-gly+4.050
gly-gly+0.912
Frac A-0.950
Frac C+0.292
Frac D-0.309
Frac E-0.583
Frac F-0.082
Frac G+0.726
Frac H-0.380
Frac I-0.900
Frac K+0.966
Frac L+0.155
Frac M-0.172
Frac N+2.712
Frac P+0.396
Frac Q+0.212
Frac R-1.304
Frac S-0.721
Frac T-0.709
Frac V+0.094
Frac W+1.825
Frac Y+1.669
Frac K+R-0.150
Frac D+E-0.594
Frac Polar+0.524
Frac Aliphatic-1.060
Frac Aromatic+1.743
R/K Ratio-2.561
E/D Ratio-0.267
Frac Chain Expanding-0.354
FCR-0.546
NCPR+0.350
Hydrophobicity-0.505
Disorder Promoting-2.199
Iso point+0.536
PPII+0.231
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+0.877
H Patch-0.077
I Patch-0.011
K Patch+2.034
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.115
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 13
Residues 1114–1164 · 50 aa (3.6% of protein) · Min inter-cluster distance: 9.885
Blocks of negative, P, & polar residues
Sequence
HQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPM
Top exceptional features (|z-score| rank)
pol-neg: +5.58neg-pro: +5.04neg-neg: +3.50hyd-hyd: -1.89pol-pol: +1.78E Patch: +1.39R/K Ratio: +1.33Frac M: +1.23
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.782
pol-hyd+0.419
pol-pos+0.000
pol-neg+5.582
pol-aro+0.000
pol-ala+0.000
pol-pro+0.733
pol-gly+0.000
hyd-hyd-1.893
hyd-pos+0.000
hyd-neg+0.668
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.148
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+3.504
neg-aro+0.000
neg-ala+0.000
neg-pro+5.036
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.951
pro-gly+0.000
gly-gly+0.000
Frac A-0.320
Frac C-0.582
Frac D+0.691
Frac E+0.449
Frac F+0.324
Frac G-0.377
Frac H-0.118
Frac I+0.108
Frac K-1.083
Frac L+0.038
Frac M+1.226
Frac N-0.989
Frac P+0.382
Frac Q+0.564
Frac R-0.115
Frac S-0.375
Frac T+0.511
Frac V+0.881
Frac W-0.508
Frac Y-0.609
Frac K+R-0.883
Frac D+E+0.675
Frac Polar-0.420
Frac Aliphatic+0.555
Frac Aromatic-0.377
R/K Ratio+1.328
E/D Ratio-0.117
Frac Chain Expanding+0.190
FCR-0.070
NCPR-1.092
Hydrophobicity+0.440
Disorder Promoting-0.034
Iso point-1.112
PPII+0.458
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+1.387
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 13
Residues 1184–1378 · 194 aa (14.1% of protein) · Min inter-cluster distance: 10.619
Blocks of negative, P, & polar residues
Sequence
WHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL
Top exceptional features (|z-score| rank)
neg-pro: +6.70pol-neg: +4.93pol-hyd: +3.09pol-pro: +2.59pro-pro: +2.49pol-pol: +2.26neg-neg: +1.94hyd-pro: +1.40
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+2.258
pol-hyd+3.091
pol-pos+0.000
pol-neg+4.928
pol-aro+0.000
pol-ala+0.000
pol-pro+2.592
pol-gly+0.000
hyd-hyd+1.362
hyd-pos+0.000
hyd-neg-0.139
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+1.404
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+1.938
neg-aro+0.000
neg-ala+0.000
neg-pro+6.695
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+2.493
pro-gly+0.000
gly-gly+0.000
Frac A-0.191
Frac C-0.582
Frac D+0.627
Frac E-0.579
Frac F+0.359
Frac G+0.070
Frac H+0.094
Frac I+0.139
Frac K-0.442
Frac L+0.386
Frac M+0.229
Frac N+0.003
Frac P-0.068
Frac Q+0.163
Frac R-0.078
Frac S+0.212
Frac T+0.220
Frac V-0.181
Frac W-0.039
Frac Y+0.307
Frac K+R-0.381
Frac D+E-0.144
Frac Polar+0.292
Frac Aliphatic+0.087
Frac Aromatic+0.414
R/K Ratio+0.379
E/D Ratio-1.064
Frac Chain Expanding-0.467
FCR-0.358
NCPR-0.142
Hydrophobicity+0.295
Disorder Promoting-0.331
Iso point-0.675
PPII-0.349
A Patch-0.265
C Patch-0.009
D Patch+1.281
E Patch+0.099
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.010
Q Patch-0.160
R Patch-0.247
S Patch+0.101
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130