NephVar / Molecular Grammars / INF2

INF2 INF2

SRNS panel · 1249 aa · UniProt Q27J81 · 4 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 19
Residues 0–31 · 31 aa (2.5% of protein) · Min inter-cluster distance: 2.155
High negative fraction, specifically Es
Sequence
MSVKEGAQRKWAALKEKLGPQDSDPTEANLE
Top exceptional features (|z-score| rank)
Frac W: +2.43pol-neg: -1.41Frac Aliphatic: +1.38Frac Polar: -1.23Frac K: +1.21R/K Ratio: -1.10Frac L: +1.09pos-ala: -1.00
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.245
pol-hyd+0.237
pol-pos+0.843
pol-neg-1.408
pol-aro+0.000
pol-ala+0.366
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.295
hyd-pos-0.745
hyd-neg-0.520
hyd-aro+0.000
hyd-ala-0.490
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.277
pos-neg+0.579
pos-aro+0.000
pos-ala-0.998
pos-pro+0.000
pos-gly+0.000
neg-neg-0.529
neg-aro+0.000
neg-ala+0.125
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.115
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+0.947
Frac C-0.582
Frac D+0.319
Frac E+0.585
Frac F-0.807
Frac G-0.304
Frac H-0.849
Frac I-0.900
Frac K+1.209
Frac L+1.091
Frac M+0.828
Frac N+0.046
Frac P-0.689
Frac Q+0.222
Frac R-0.665
Frac S-0.907
Frac T-0.560
Frac V-0.132
Frac W+2.427
Frac Y-0.609
Frac K+R+0.457
Frac D+E+0.601
Frac Polar-1.226
Frac Aliphatic+1.376
Frac Aromatic+0.079
R/K Ratio-1.100
E/D Ratio+0.116
Frac Chain Expanding+0.386
FCR+0.751
NCPR-0.154
Hydrophobicity-0.024
Disorder Promoting-0.498
Iso point-0.809
PPII-0.033
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 1
Residues 344–517 · 173 aa (13.9% of protein) · Min inter-cluster distance: 30.743
Blocks of P & polar residues
Sequence
KGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPP
Top exceptional features (|z-score| rank)
pol-pro: +7.88pro-pro: +7.56P Patch: +3.65Frac P: +3.40hyd-pro: +3.37PPII: +3.22pol-pol: +3.10pol-hyd: +2.19
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+3.098
pol-hyd+2.185
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+7.880
pol-gly+0.000
hyd-hyd-0.403
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+3.369
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+7.562
pro-gly+0.000
gly-gly+0.000
Frac A+0.383
Frac C+0.600
Frac D-0.956
Frac E-0.833
Frac F-0.480
Frac G-0.132
Frac H-0.426
Frac I-0.609
Frac K-0.467
Frac L+1.134
Frac M-0.237
Frac N-0.618
Frac P+3.397
Frac Q+0.073
Frac R-0.846
Frac S-0.661
Frac T-0.635
Frac V-0.044
Frac W+0.018
Frac Y-0.609
Frac K+R-0.912
Frac D+E-1.095
Frac Polar-0.978
Frac Aliphatic+0.694
Frac Aromatic-0.692
R/K Ratio-0.488
E/D Ratio+0.564
Frac Chain Expanding+0.763
FCR-1.421
NCPR+0.228
Hydrophobicity+1.155
Disorder Promoting+0.132
Iso point+0.401
PPII+3.218
A Patch+0.313
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+3.650
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 23
Residues 926–968 · 42 aa (3.4% of protein) · Min inter-cluster distance: 0.018
K blocks
Sequence
NKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQE
Top exceptional features (|z-score| rank)
Frac K+R: +2.73Hydrophobicity: -2.69FCR: +2.42Frac Chain Expanding: +2.41Disorder Promoting: +2.27Frac R: +2.00Frac K: +1.88Frac S: -1.87
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.809
pol-hyd+0.000
pol-pos+0.038
pol-neg+0.694
pol-aro+0.000
pol-ala+0.004
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.000
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos-0.213
pos-neg+0.293
pos-aro+0.000
pos-ala-0.074
pos-pro+0.000
pos-gly+0.000
neg-neg+0.740
neg-aro+0.000
neg-ala-0.646
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.940
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A+0.764
Frac C-0.582
Frac D-0.088
Frac E+1.151
Frac F-0.807
Frac G+0.193
Frac H-0.849
Frac I-0.900
Frac K+1.877
Frac L-0.999
Frac M-0.832
Frac N-0.225
Frac P-0.591
Frac Q+0.902
Frac R+2.001
Frac S-1.874
Frac T-1.284
Frac V-0.441
Frac W-0.508
Frac Y-0.609
Frac K+R+2.733
Frac D+E+0.839
Frac Polar-1.656
Frac Aliphatic-0.642
Frac Aromatic-1.123
R/K Ratio-0.133
E/D Ratio+0.742
Frac Chain Expanding+2.406
FCR+2.421
NCPR+1.163
Hydrophobicity-2.685
Disorder Promoting+2.275
Iso point+0.939
PPII+0.750
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 4 Cluster 5
Residues 983–1249 · 266 aa (21.3% of protein) · Min inter-cluster distance: 13.525
Blocks of positive, negative & P residues
Sequence
FQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ
Top exceptional features (|z-score| rank)
pos-neg: +5.80hyd-pos: +3.44pos-pro: +2.65neg-pro: +2.52pos-pos: +2.40pos-ala: +1.90pro-pro: +1.63neg-ala: +1.54
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.170
pol-hyd+0.019
pol-pos+0.996
pol-neg+0.649
pol-aro+0.000
pol-ala-0.431
pol-pro-0.173
pol-gly+0.000
hyd-hyd-0.069
hyd-pos+3.443
hyd-neg+1.051
hyd-aro+0.000
hyd-ala+0.125
hyd-pro+0.690
hyd-gly+0.000
pos-pos+2.400
pos-neg+5.799
pos-aro+0.000
pos-ala+1.895
pos-pro+2.652
pos-gly+0.000
neg-neg+1.232
neg-aro+0.000
neg-ala+1.544
neg-pro+2.516
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala-0.163
ala-pro-0.741
ala-gly+0.000
pro-pro+1.629
pro-gly+0.000
gly-gly+0.000
Frac A+0.511
Frac C+0.187
Frac D+1.119
Frac E-0.224
Frac F-0.169
Frac G+0.172
Frac H-0.712
Frac I-0.711
Frac K-0.215
Frac L+0.365
Frac M-0.638
Frac N-0.627
Frac P-0.111
Frac Q-0.291
Frac R+0.112
Frac S-0.240
Frac T+0.403
Frac V+0.337
Frac W+0.518
Frac Y-0.386
Frac K+R-0.085
Frac D+E+0.363
Frac Polar-0.362
Frac Aliphatic+0.381
Frac Aromatic-0.142
R/K Ratio+0.243
E/D Ratio-0.899
Frac Chain Expanding+0.175
FCR+0.217
NCPR-0.331
Hydrophobicity+0.326
Disorder Promoting+0.452
Iso point-0.944
PPII-0.220
A Patch-0.265
C Patch-0.009
D Patch+0.768
E Patch-0.022
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch+0.456
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac+0.097