NephVar / Molecular Grammars / HNF1B

HNF1B HNF1B

CAKUT panel · 557 aa · UniProt P35680 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 13
Residues 41–90 · 49 aa (8.8% of protein) · Min inter-cluster distance: 3.085
Blocks of negative, P, & polar residues
Sequence
KLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPP
Top exceptional features (|z-score| rank)
D Patch: +3.67hyd-neg: +2.60neg-neg: +2.15Frac D: +1.71neg-pro: +1.71pol-pol: -1.69pol-neg: +1.60pol-hyd: -1.47
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.694
pol-hyd-1.470
pol-pos+0.000
pol-neg+1.597
pol-aro+0.000
pol-ala+0.000
pol-pro-0.048
pol-gly-0.707
hyd-hyd+0.527
hyd-pos+0.000
hyd-neg+2.602
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.866
hyd-gly+0.959
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+2.150
neg-aro+0.000
neg-ala+0.000
neg-pro+1.706
neg-gly-0.252
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.312
pro-gly+0.546
gly-gly-0.129
Frac A-0.671
Frac C-0.582
Frac D+1.713
Frac E-0.127
Frac F+0.347
Frac G+0.963
Frac H+0.644
Frac I-0.900
Frac K+0.004
Frac L+1.242
Frac M-0.832
Frac N-0.335
Frac P+0.133
Frac Q-1.207
Frac R-0.900
Frac S-0.650
Frac T+1.006
Frac V-0.565
Frac W-0.508
Frac Y+0.600
Frac K+R-0.597
Frac D+E+0.722
Frac Polar+0.050
Frac Aliphatic-0.697
Frac Aromatic+0.398
R/K Ratio-0.864
E/D Ratio-1.013
Frac Chain Expanding+0.273
FCR+0.152
NCPR-0.939
Hydrophobicity+0.065
Disorder Promoting+0.259
Iso point-1.011
PPII-0.587
A Patch-0.265
C Patch-0.009
D Patch+3.672
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 6
Residues 319–379 · 60 aa (10.8% of protein) · Min inter-cluster distance: 6.28
S patches
Sequence
SNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMVTSQS
Top exceptional features (|z-score| rank)
Frac Polar: +2.96Frac H: +2.81Frac Chain Expanding: -2.51Frac N: +2.22Frac S: +2.12FCR: -1.89Frac D+E: -1.44Frac K+R: -1.24
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.503
pol-hyd-0.394
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd+0.124
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-1.115
Frac C-0.582
Frac D-1.234
Frac E-1.103
Frac F-0.807
Frac G-0.269
Frac H+2.810
Frac I+0.780
Frac K-0.787
Frac L+0.229
Frac M+0.026
Frac N+2.219
Frac P-0.422
Frac Q+0.638
Frac R-0.974
Frac S+2.123
Frac T+0.212
Frac V-0.093
Frac W-0.508
Frac Y+0.378
Frac K+R-1.236
Frac D+E-1.435
Frac Polar+2.957
Frac Aliphatic-0.642
Frac Aromatic-0.502
R/K Ratio-0.133
E/D Ratio+0.358
Frac Chain Expanding-2.507
FCR-1.889
NCPR+0.272
Hydrophobicity+0.202
Disorder Promoting-1.232
Iso point+0.805
PPII-1.138
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch+0.649
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 10
Residues 380–410 · 30 aa (5.4% of protein) · Min inter-cluster distance: 10.723
Well-mixed hydrophobics, enriched in M
Sequence
LQQVSPASLDPGHNLLSPDGKMISVSGGGL
Top exceptional features (|z-score| rank)
Frac L: +3.09Disorder Promoting: -2.43Hydrophobicity: +2.40Frac Aliphatic: +2.08E/D Ratio: -2.03Frac Chain Expanding: -1.83FCR: -1.46Frac E: -1.35
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.747
pol-hyd-1.155
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.159
hyd-hyd-0.695
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly-0.314
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.448
Frac A-0.809
Frac C-0.582
Frac D+0.370
Frac E-1.354
Frac F-0.807
Frac G+1.348
Frac H+0.370
Frac I+0.780
Frac K-0.491
Frac L+3.093
Frac M+0.883
Frac N+0.080
Frac P-0.185
Frac Q+0.269
Frac R-1.304
Frac S+0.624
Frac T-1.284
Frac V+1.125
Frac W-0.508
Frac Y-0.609
Frac K+R-1.236
Frac D+E-0.860
Frac Polar+0.826
Frac Aliphatic+2.078
Frac Aromatic-1.123
R/K Ratio-0.864
E/D Ratio-2.028
Frac Chain Expanding-1.833
FCR-1.456
NCPR-0.163
Hydrophobicity+2.401
Disorder Promoting-2.430
Iso point-0.675
PPII-1.031
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130