NephVar / Molecular Grammars / RPGRIP1L

RPGRIP1L FTM

NPHP panel · 1315 aa · UniProt Q68CZ1 · 3 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 15
Residues 0–45 · 45 aa (3.4% of protein) · Min inter-cluster distance: 4.246
T patches
Sequence
MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRV
Top exceptional features (|z-score| rank)
T Patch: +3.89Frac M: +2.60Frac T: +2.21pol-gly: +1.93pos-gly: +1.89hyd-gly: -1.53PPII: -1.27Hydrophobicity: +1.26
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.464
pol-hyd+0.766
pol-pos-0.321
pol-neg-0.052
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+1.927
hyd-hyd-0.021
hyd-pos-0.837
hyd-neg-0.065
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly-1.533
pos-pos+0.733
pos-neg+1.205
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+1.894
neg-neg+0.360
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.150
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.112
Frac A-0.605
Frac C-0.582
Frac D+0.370
Frac E-0.686
Frac F+0.450
Frac G+0.809
Frac H-0.849
Frac I-0.900
Frac K-0.294
Frac L+0.865
Frac M+2.598
Frac N-0.276
Frac P-0.973
Frac Q-0.223
Frac R+0.018
Frac S-0.542
Frac T+2.206
Frac V+1.125
Frac W-0.508
Frac Y-0.609
Frac K+R-0.207
Frac D+E-0.348
Frac Polar+0.608
Frac Aliphatic+0.990
Frac Aromatic-0.295
R/K Ratio+0.170
E/D Ratio-0.948
Frac Chain Expanding-1.158
FCR-0.398
NCPR+0.127
Hydrophobicity+1.261
Disorder Promoting-1.232
Iso point-0.137
PPII-1.274
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch+3.887
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 28
Residues 139–173 · 34 aa (2.6% of protein) · Min inter-cluster distance: 3.269
High aromatic fraction, specifically Ys
Sequence
LQTQGYRQTPYNNVQSRINTGRRKANENAGLQEC
Top exceptional features (|z-score| rank)
Frac N: +3.73Frac Y: +2.88Disorder Promoting: -2.78Frac Q: +2.05pol-hyd: -1.60Frac Chain Expanding: -1.48Frac Polar: +1.44Frac S: -1.43
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.510
pol-hyd-1.601
pol-pos-0.499
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-0.535
hyd-pos+1.125
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+0.000
hyd-gly+0.000
pos-pos+0.183
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.000
pro-gly+0.000
gly-gly+0.000
Frac A-0.341
Frac C+1.424
Frac D-1.234
Frac E-0.470
Frac F-0.807
Frac G+0.079
Frac H-0.849
Frac I+0.583
Frac K-0.561
Frac L+0.004
Frac M-0.832
Frac N+3.728
Frac P-1.186
Frac Q+2.050
Frac R+1.029
Frac S-1.433
Frac T+0.696
Frac V-0.236
Frac W-0.508
Frac Y+2.875
Frac K+R+0.269
Frac D+E-0.950
Frac Polar+1.443
Frac Aliphatic-0.482
Frac Aromatic+1.069
R/K Ratio+0.833
E/D Ratio+0.898
Frac Chain Expanding-1.476
FCR-0.539
NCPR+0.895
Hydrophobicity-0.823
Disorder Promoting-2.782
Iso point+0.872
PPII-0.908
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 24
Residues 953–1090 · 137 aa (10.4% of protein) · Min inter-cluster distance: 1.048
Weak negative charge
Sequence
STLVLAPRPKPRQRLTPVDKKVSFVDIMPHQSDETSPPPEDRKEISPEVEHIPEIEINMLTVPHVPKVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPG
Top exceptional features (|z-score| rank)
Frac I: +2.04Frac V: +1.89neg-pro: +1.37E Patch: +1.34Disorder Promoting: -1.29NCPR: -1.27Frac D+E: +1.23pol-hyd: -1.08
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-0.449
pol-hyd-1.078
pol-pos+0.000
pol-neg-0.470
pol-aro+0.000
pol-ala+0.000
pol-pro+0.222
pol-gly+0.000
hyd-hyd-0.494
hyd-pos+0.000
hyd-neg-0.018
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.139
hyd-gly+0.000
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.696
neg-aro+0.000
neg-ala+0.000
neg-pro+1.373
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.533
pro-gly+0.000
gly-gly+0.000
Frac A-0.885
Frac C-0.085
Frac D+1.050
Frac E+0.950
Frac F-0.394
Frac G-0.875
Frac H-0.048
Frac I+2.044
Frac K-0.046
Frac L+0.201
Frac M+0.671
Frac N-0.521
Frac P-0.154
Frac Q-0.076
Frac R-0.725
Frac S-0.233
Frac T-0.137
Frac V+1.889
Frac W-0.508
Frac Y-0.609
Frac K+R-0.518
Frac D+E+1.229
Frac Polar-0.964
Frac Aliphatic+1.045
Frac Aromatic-0.851
R/K Ratio-0.753
E/D Ratio+0.037
Frac Chain Expanding+0.574
FCR+0.586
NCPR-1.271
Hydrophobicity+0.635
Disorder Promoting-1.293
Iso point-1.078
PPII+0.274
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch+1.341
F Patch-0.012
G Patch-0.259
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130