NephVar / Molecular Grammars / COL4A6

COL4A6 CO4A6

CGN panel · 1691 aa · UniProt Q14031 · 8 IDRs · View biophysical profile →
IDR map — colored by GIN molecular grammar cluster
IDR 1 Cluster 22
Residues 94–333 · 239 aa (14.1% of protein) · Min inter-cluster distance: 50.241
Well-mixed P and G
GPMGVPGFLGINGIPGHPGQPGPRGPPGLDGCNGTQGAVGFPGPDGYPGLLGPPGLPGQKGSKGDPVLAPGSFKGMKGDPGLPGLDGITGPQGAPGFPGAVGPAGPPGLQGPPGPPGPLGPDGNMGLGFQGEKGVKGDVGLPGPAGPPPSTGELEFMGFPKGKKGSKGEPGPKGFPGISGPPGFPGLGTTGEKGEKGEKGIPGLPGPRGPMGSEGVQGPPGQQGKKGTLGFPGLNGFQG
G Patch: +9.65gly-gly: -4.42Frac G: +3.86hyd-gly: -3.53pol-gly: -3.53pro-gly: -2.91R/K Ratio: -1.96Frac F: +1.80
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.593
pol-hyd+0.219
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+1.536
pol-gly-3.527
hyd-hyd-1.074
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.327
hyd-gly-3.531
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.848
pro-gly-2.906
gly-gly-4.416
Frac A-0.960
Frac C-0.297
Frac D-0.529
Frac E-0.851
Frac F+1.796
Frac G+3.862
Frac H-0.696
Frac I+0.154
Frac K+0.106
Frac L+0.357
Frac M+0.245
Frac N-0.452
Frac P+1.304
Frac Q-0.281
Frac R-1.139
Frac S-1.497
Frac T-0.721
Frac V-0.241
Frac W-0.508
Frac Y-0.361
Frac K+R-0.681
Frac D+E-0.905
Frac Polar+0.557
Frac Aliphatic-0.630
Frac Aromatic+0.748
R/K Ratio-1.963
E/D Ratio-0.408
Frac Chain Expanding-0.385
FCR-1.126
NCPR+0.236
Hydrophobicity+1.236
Disorder Promoting-0.275
Iso point+0.536
PPII+0.226
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+9.654
H Patch-0.077
I Patch-0.011
K Patch+0.327
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.406
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 2 Cluster 22
Residues 360–390 · 30 aa (1.8% of protein) · Min inter-cluster distance: 10.411
Well-mixed P and G
PGDPGVPGLPGLKGDEGIQGLRGPSGVPGL
G Patch: +10.07Frac G: +4.04P Patch: +3.24Frac L: +2.14Hydrophobicity: +1.75Frac A: -1.42Frac S: -1.37gly-gly: -1.35
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.000
pol-hyd+0.000
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.000
pol-gly+0.000
hyd-hyd-1.254
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.933
hyd-gly-1.307
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.397
pro-gly-0.955
gly-gly-1.350
Frac A-1.420
Frac C-0.582
Frac D+0.370
Frac E-0.853
Frac F-0.807
Frac G+4.043
Frac H-0.849
Frac I+0.780
Frac K-0.491
Frac L+2.139
Frac M-0.832
Frac N-0.989
Frac P+1.233
Frac Q-0.469
Frac R-0.643
Frac S-1.374
Frac T-1.284
Frac V+1.125
Frac W-0.508
Frac Y-0.609
Frac K+R-0.795
Frac D+E-0.476
Frac Polar+0.170
Frac Aliphatic+0.446
Frac Aromatic-1.123
R/K Ratio-0.133
E/D Ratio-1.105
Frac Chain Expanding-0.147
FCR-0.879
NCPR-0.163
Hydrophobicity+1.751
Disorder Promoting-0.633
Iso point-0.977
PPII+0.018
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+10.074
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+3.244
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 3 Cluster 22
Residues 391–473 · 82 aa (4.8% of protein) · Min inter-cluster distance: 16.785
Well-mixed P and G
ALSGVPGALGPQGFPGLKGDQGNPGRTTIGAAGLPGRDGLPGPPGPPGPPSPEFETETLHNKESGFPGLRGEQGPKGNLGLK
G Patch: +7.44Frac G: +2.79pol-pro: +1.90hyd-gly: -1.71pro-gly: -1.54Frac L: +1.46Frac S: -1.32hyd-pro: +1.31
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.086
pol-hyd-0.607
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+1.895
pol-gly+0.095
hyd-hyd-1.188
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro+1.310
hyd-gly-1.709
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.372
pro-gly-1.544
gly-gly-1.088
Frac A-0.525
Frac C-0.582
Frac D-0.647
Frac E-0.437
Frac F+1.262
Frac G+2.794
Frac H-0.403
Frac I-0.285
Frac K-0.217
Frac L+1.463
Frac M-0.832
Frac N+0.184
Frac P+0.991
Frac Q-0.397
Frac R-0.579
Frac S-1.325
Frac T-0.189
Frac V-0.865
Frac W-0.508
Frac Y-0.609
Frac K+R-0.548
Frac D+E-0.645
Frac Polar+0.434
Frac Aliphatic-0.376
Frac Aromatic+0.240
R/K Ratio-0.369
E/D Ratio+0.358
Frac Chain Expanding-0.279
FCR-0.844
NCPR+0.127
Hydrophobicity+0.866
Disorder Promoting-0.166
Iso point-0.137
PPII+0.044
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+7.437
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.174
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 4 Cluster 22
Residues 484–655 · 171 aa (10.1% of protein) · Min inter-cluster distance: 59.642
Well-mixed P and G
DGGVPNTGPPGEPGPPGPWGLIGLPGLKGARGDRGSGGAQGPAGAPGLVGPLGPSGPKGKKGEPILSTIQGMPGDRGDSGSQGFRGVIGEPGKDGVPGLPGLPGLPGDGGQGFPGEKGLPGLPGEKGHPGPPGLPGNGLPGLPGPRGLPGDKGKDGLPGQQGLPGSKGITL
RG Frac: +13.34G Patch: +9.65Frac G: +4.04gly-gly: -3.32pol-gly: -2.75pro-gly: -2.70hyd-gly: -1.83pol-pol: +1.53
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.527
pol-hyd+0.558
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.920
pol-gly-2.751
hyd-hyd+0.762
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.139
hyd-gly-1.828
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-1.444
pro-gly-2.697
gly-gly-3.316
Frac A-0.991
Frac C-0.582
Frac D-0.108
Frac E-0.914
Frac F-0.146
Frac G+4.043
Frac H-0.635
Frac I+0.574
Frac K-0.044
Frac L+1.334
Frac M-0.531
Frac N-0.614
Frac P+1.133
Frac Q-0.430
Frac R-0.725
Frac S-1.348
Frac T-0.890
Frac V-0.456
Frac W+0.024
Frac Y-0.609
Frac K+R-0.516
Frac D+E-0.752
Frac Polar+0.550
Frac Aliphatic-0.308
Frac Aromatic-0.469
R/K Ratio-0.773
E/D Ratio-1.105
Frac Chain Expanding-0.248
FCR-0.904
NCPR+0.229
Hydrophobicity+1.115
Disorder Promoting+0.092
Iso point+0.603
PPII-0.021
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+9.647
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+1.302
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac+13.344
IDR 5 Cluster 22
Residues 661–900 · 239 aa (14.1% of protein) · Min inter-cluster distance: 58.834
Well-mixed P and G
SYGPSGFPGTPGFPGPKGSRGLPGTPGQPGSSGSKGEPGSPGLVHLPELPGFPGPRGEKGLPGFPGLPGKDGLPGMIGSPGLPGSKGATGDIFGAENGAPGEQGLQGLTGHKGFLGDSGLPGLKGVHGKPGLLGPKGERGSPGTPGQVGQPGTPGSSGPYGIKGKSGLPGAPGFPGISGHPGKKGTRGKKGPPGSIVKKGLPGLKGLPGNPGLVGLKGSPGSPGVAGLPALSGPKGEKG
G Patch: +9.24RG Frac: +5.98gly-gly: -4.34pro-gly: -3.75Frac G: +3.73pos-gly: -3.47pol-gly: -3.44hyd-gly: -2.71
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol-1.090
pol-hyd+0.103
pol-pos+0.275
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro-1.767
pol-gly-3.439
hyd-hyd+0.221
hyd-pos+0.537
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.981
hyd-gly-2.709
pos-pos+1.053
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.116
pos-gly-3.469
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-2.463
pro-gly-3.745
gly-gly-4.339
Frac A-0.960
Frac C-0.582
Frac D-0.932
Frac E-0.914
Frac F+0.849
Frac G+3.727
Frac H-0.237
Frac I+0.154
Frac K+0.478
Frac L+1.076
Frac M-0.616
Frac N-0.721
Frac P+0.889
Frac Q-0.744
Frac R-0.973
Frac S-0.682
Frac T-0.627
Frac V-0.394
Frac W-0.508
Frac Y-0.113
Frac K+R-0.293
Frac D+E-1.145
Frac Polar+0.845
Frac Aliphatic-0.562
Frac Aromatic+0.280
R/K Ratio-1.696
E/D Ratio+0.358
Frac Chain Expanding-0.597
FCR-1.054
NCPR+0.673
Hydrophobicity+1.243
Disorder Promoting+0.101
Iso point+0.872
PPII-0.254
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+9.237
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.387
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac+5.982
IDR 6 Cluster 22
Residues 914–1100 · 186 aa (11.0% of protein) · Min inter-cluster distance: 66.422
Well-mixed P and G
GIPGTRGLKGIPGSTGKMGPSGRAGTPGEKGDRGNPGPVGIPSPRRPMSNLWLKGDKGSQGSAGSNGFPGPRGDKGEAGRPGPPGLPGAPGLPGIIKGVSGKPGPPGFMGIRGLPGLKGSSGITGFPGMPGESGSQGIRGSPGLPGASGLPGLKGDNGQTVEISGSPGPKGQPGESGFKGTKGRDG
G Patch: +9.44RG Frac: +8.05Frac G: +3.61pos-gly: -2.88gly-gly: -2.83pro-gly: -2.56pol-gly: -2.29hyd-gly: -2.15
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+0.276
pol-hyd+0.321
pol-pos+0.378
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+1.669
pol-gly-2.285
hyd-hyd+0.206
hyd-pos-0.636
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-0.575
hyd-gly-2.154
pos-pos-1.120
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro-0.088
pos-gly-2.882
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro+0.490
pro-gly-2.565
gly-gly-2.825
Frac A-0.927
Frac C-0.582
Frac D-0.587
Frac E-0.950
Frac F+0.409
Frac G+3.608
Frac H-0.849
Frac I+1.539
Frac K+0.158
Frac L-0.141
Frac M+0.275
Frac N-0.299
Frac P+0.608
Frac Q-0.731
Frac R-0.238
Frac S-0.504
Frac T-0.560
Frac V-0.722
Frac W-0.019
Frac Y-0.609
Frac K+R-0.041
Frac D+E-1.008
Frac Polar+0.890
Frac Aliphatic-0.642
Frac Aromatic-0.121
R/K Ratio-0.388
E/D Ratio-0.565
Frac Chain Expanding-0.484
FCR-0.786
NCPR+0.736
Hydrophobicity+0.882
Disorder Promoting+0.178
Iso point+1.208
PPII-0.405
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+9.443
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.327
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac+8.047
IDR 7 Cluster 22
Residues 1129–1160 · 31 aa (1.8% of protein) · Min inter-cluster distance: 7.656
Well-mixed P and G
GFPGVAGMRGEPGLPGSSGHQGAIGPLGSPG
G Patch: +10.81Frac G: +4.39pol-hyd: +2.07Hydrophobicity: +2.04FCR: -1.76pol-pro: +1.60pol-pol: +1.60Frac Chain Expanding: -1.57
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.596
pol-hyd+2.069
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+1.604
pol-gly-0.785
hyd-hyd-1.459
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.158
hyd-gly-1.534
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-0.428
pro-gly-1.269
gly-gly-1.214
Frac A-0.237
Frac C-0.582
Frac D-1.234
Frac E-0.869
Frac F+1.017
Frac G+4.391
Frac H+0.331
Frac I+0.726
Frac K-1.083
Frac L+0.167
Frac M+0.828
Frac N-0.989
Frac P+0.684
Frac Q-0.493
Frac R-0.665
Frac S-0.423
Frac T-1.284
Frac V-0.132
Frac W-0.508
Frac Y-0.609
Frac K+R-1.250
Frac D+E-1.256
Frac Polar+1.313
Frac Aliphatic+0.323
Frac Aromatic+0.079
R/K Ratio+0.598
E/D Ratio+0.358
Frac Chain Expanding-1.572
FCR-1.763
NCPR+0.127
Hydrophobicity+2.040
Disorder Promoting+0.082
Iso point+0.939
PPII-0.887
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+10.812
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch-0.447
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac-0.130
IDR 8 Cluster 22
Residues 1171–1461 · 290 aa (17.1% of protein) · Min inter-cluster distance: 56.916
Well-mixed P and G
GLHGLNGLPGTKGTHGTPGPSITGVPGPAGLPGPKGEKGYPGIGIGAPGKPGLRGQKGDRGFPGLQGPAGLPGAPGISLPSLIAGQPGDPGRPGLDGERGRPGPAGPPGPPGPSSNQGDTGDPGFPGIPGPKGPKGDQGIPGFSGLPGELGLKGMRGEPGFMGTPGKVGPPGDPGFPGMKGKAGPRGSSGLQGDPGQTPTAEAVQVPPGPLGLPGIDGIPGLTGDPGAQGPVGLQGSKGLPGIPGKDGPSGLPGPPGALGDPGLPGLQGPPGFEGAPGQQGPFGMPGMPG
G Patch: +9.71RG Frac: +6.72gly-gly: -4.11pro-gly: -4.02Frac G: +3.73hyd-gly: -3.39pro-pro: -2.83pol-gly: -2.43
Show all 90 sequence-feature z-scores
FeatureZ-score
pol-pol+1.080
pol-hyd+0.149
pol-pos+0.000
pol-neg+0.000
pol-aro+0.000
pol-ala+0.000
pol-pro+0.578
pol-gly-2.432
hyd-hyd-0.646
hyd-pos+0.000
hyd-neg+0.000
hyd-aro+0.000
hyd-ala+0.000
hyd-pro-1.633
hyd-gly-3.391
pos-pos+0.000
pos-neg+0.000
pos-aro+0.000
pos-ala+0.000
pos-pro+0.000
pos-gly+0.000
neg-neg+0.000
neg-aro+0.000
neg-ala+0.000
neg-pro+0.000
neg-gly+0.000
aro-aro+0.000
aro-ala+0.000
aro-pro+0.000
aro-gly+0.000
ala-ala+0.000
ala-pro+0.000
ala-gly+0.000
pro-pro-2.832
pro-gly-4.022
gly-gly-4.109
Frac A-0.661
Frac C-0.582
Frac D-0.238
Frac E-1.043
Frac F+0.558
Frac G+3.727
Frac H-0.597
Frac I+0.838
Frac K-0.287
Frac L+0.591
Frac M+0.055
Frac N-0.768
Frac P+1.428
Frac Q-0.215
Frac R-0.826
Frac S-1.357
Frac T-0.587
Frac V-0.681
Frac W-0.508
Frac Y-0.405
Frac K+R-0.765
Frac D+E-0.913
Frac Polar+0.544
Frac Aliphatic-0.267
Frac Aromatic-0.095
R/K Ratio-0.724
E/D Ratio-1.389
Frac Chain Expanding-0.368
FCR-1.187
NCPR+0.187
Hydrophobicity+1.244
Disorder Promoting+0.275
Iso point+0.536
PPII+0.339
A Patch-0.265
C Patch-0.009
D Patch-0.178
E Patch-0.349
F Patch-0.012
G Patch+9.705
H Patch-0.077
I Patch-0.011
K Patch-0.253
L Patch-0.096
M Patch-0.026
N Patch-0.076
P Patch+0.775
Q Patch-0.160
R Patch-0.247
S Patch-0.481
T Patch-0.147
V Patch-0.051
Y Patch-0.022
RG Frac+6.725